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Randomized Controlled Trial
. 2020 Aug;18(3):268-277.
doi: 10.1111/idh.12432. Epub 2020 Mar 20.

A randomized double-blind clinical trial to evaluate the efficacy of chlorhexidine, antioxidant, and hyaluronic acid mouthwashes in the management of biofilm-induced gingivitis

Ali A Abdulkareem  1 , Zaid A Al Marah  2 , Hayder R Abdulbaqi  1 , Ali J Alshaeli  1 , Mike R Milward  3
Affiliations
Randomized Controlled Trial

A randomized double-blind clinical trial to evaluate the efficacy of chlorhexidine, antioxidant, and hyaluronic acid mouthwashes in the management of biofilm-induced gingivitis

Ali A Abdulkareem et al. Int J Dent Hyg. 2020 Aug.

Abstract

Objectives: To investigate the antiplaque and antigingivitis efficacy in addition to evaluating side effects and subjects' perceptions of three commercially available mouthwashes.

Methods: This study was a double-blind, parallel, and short-term trial. A total of 75 dental students with biofilm-induced gingivitis were included in the final analysis of the current study. Clinical parameters (plaque index and bleeding on probing) and the staining effect were measured at baseline and after 7 days. In addition, a VAS-based assessment questionnaire was completed by the participants.

Results: All interventions significantly reduced plaque scores, but chlorhexidine (CHX) had a significantly higher effect than the hyaluronic acid (HA) and antioxidant mouthwashes. However, all mouthwashes significantly reduced the total bleeding scores to <10% in 53% of the patients, compared to the baseline record. Additionally, teeth underwent shade changes in association with all interventions by the end of the study. Analysis of feedback about the mouthwashes showed that the participants seemed to prefer the HA mouthwash over the other mouthwashes.

Conclusions: CHX remains the most effective antiplaque mouthwash although HA and antioxidants are as effective as CHX in reducing bleeding. In addition, based on its better acceptance by the participants, HA is potentially a good alternative to CHX.

Keywords: chlorhexidine; dental biofilm; mouth rinse/wash; oral hygiene; staining.

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References

REFERENCES

    1. Li Y, Lee S, Hujoel P, et al. Prevalence and severity of gingivitis in American adults. Am J Dent. 2010;23(1):9-13.
    1. Tonetti MS, Jepsen S, Jin L, Otomo-Corgel J. Impact of the global burden of periodontal diseases on health, nutrition and wellbeing of mankind: a call for global action. J Clin Periodontol. 2017;44(5):456-462.
    1. Botelho MA, Bezerra Filho JG, Correa LL, et al. Effect of a novel essential oil mouthrinse without alcohol on gingivitis: a double-blinded randomized controlled trial. J Appl Oral Sci. 2007;15(3):175-180.
    1. Botelho MA, dos Santos RA, Martins JG, et al. Comparative effect of an essential oil mouthrinse on plaque, gingivitis and salivary Streptococcus mutans levels: a double blind randomized study. Phytother Res. 2009;23(9):1214-1219.
    1. Dany SS, Mohanty P, Tangade P, Rajput P, Batra M. Efficacy of 0.25% lemongrass oil mouthwash: a three arm prospective parallel clinical study. J Clin Diag Res. 2015;9(10):13-17.

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