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Review
. 2020 May;125(2):152-157.
doi: 10.1080/03009734.2020.1729904. Epub 2020 Feb 26.

Long-term health of children conceived after assisted reproductive technology

Christina Bergh  1   2 , Ulla-Britt Wennerholm  1
Affiliations
Review

Long-term health of children conceived after assisted reproductive technology

Christina Bergh et al. Ups J Med Sci. 2020 May.

Abstract

The aim of this narrative review is to summarize the present knowledge on long-term outcome of children born after assisted reproductive technologies (ART). The main outcomes covered are neurodevelopment including cerebral palsy, cognitive development, attention deficit hyperactivity disorder and autism spectrum disease, growth, cardiovascular function, diabetes type 1, asthma, malignancies, and reproductive health. Results have mainly been obtained from systematic reviews/meta-analyses and large registry studies. It has been shown that children born after ART, when restricted to singletons, have a similar outcome for many health conditions as their spontaneously conceived peers. For some outcomes, particularly cardiovascular function and diabetes, studies show some higher risk for ART singletons or subgroup of ART singletons. The fast introduction of new ART techniques emphasizes the importance of continuous surveillance of children born after ART.

Keywords: Assisted reproductive technology; ICSI; IVF; long-term follow up.

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Conflict of interest statement

No potential conflict of interest was reported by the author(s).

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References

    1. Middelburg KJ, Heineman MJ, Bos AF. Hadders-Algra M. Neuromotor, cognitive, language and behavioural outcome in children born following IVF or ICSI-a systematic review. Hum Reprod Update. 2008;14:219–31. doi:10.1093/humupd/dmn005 - DOI - PubMed
    1. Bay B, Mortensen EL, Kesmodel US. Assisted reproduction and child neurodevelopmental outcomes: a systematic review. Fertil Steril. 2013;100:844–53. doi:10.1016/j.fertnstert.2013.05.034 - DOI - PubMed
    1. Hart R, Norman RJ. The longer-term health outcomes for children born as a result of IVF treatment. Part II–Mental health and development outcomes. Hum Reprod Update. 2013;19:244–50. doi:10.1093/humupd/dmt002 - DOI - PubMed
    1. Rumbold AR, Moore VM, Whitrow MJ, Oswald TK, Moran LJ, Fernandez RC, et al. . The impact of specific fertility treatments on cognitive development in childhood and adolescence: a systematic review. Hum Reprod. 2017;32:1489–507. doi:10.1093/humrep/dex085 - DOI - PubMed
    1. Stromberg B, Dahlquist G, Ericson A, Finnstrom O, Koster M, Stjernqvist K. Neurological sequelae in children born after in-vitro fertilisation: a population-based study. Lancet 2002;359:461–5. doi:10.1016/S0140-6736(02)07674-2 - DOI - PubMed