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. 2020 Feb 5;3(2):e200038.
doi: 10.1001/jamanetworkopen.2020.0038.

Risk Factors for Long-term Mortality and Patterns of End-of-Life Care Among Medicare Sepsis Survivors Discharged to Home Health Care

Katherine R Courtright  1   2 , Lizeyka Jordan  3 , Christopher M Murtaugh  3 , Yolanda Barrón  3 , Partha Deb  4   5 , Stanley Moore  3 , Kathryn H Bowles  3   6 , Mark E Mikkelsen  1   2
Affiliations

Risk Factors for Long-term Mortality and Patterns of End-of-Life Care Among Medicare Sepsis Survivors Discharged to Home Health Care

Katherine R Courtright et al. JAMA Netw Open. .

Abstract

Importance: Despite a growing recognition of the increased mortality risk among sepsis survivors, little is known about the patterns of end-of-life care among this population.

Objective: To describe patterns of end-of-life care among a national sample of sepsis survivors and identify factors associated with long-term mortality risk and hospice use.

Design, setting, and participants: This cohort study assessed sepsis survivors who were Medicare fee-for-service beneficiaries discharged to home health care using national Medicare administrative, claims, and home health assessment data from 2013 to 2014. The initial and final primary analyses were conducted in July 2017 and from July to August 2019, respectively.

Exposures: Sepsis hospital discharge and 1 or more home health assessments within 1 week.

Main outcomes and measures: Outcomes were 1-year mortality among all sepsis survivors and hospitalization in the last 30 days of life, death in an acute care hospital, and hospice use among decedents. Multivariate logistic regression was used to identify factors associated with 1-year mortality and hospice use.

Results: Among 87 581 sepsis survivors who were Medicare fee-for-service beneficiaries discharged to home health care, 49 323 (56.3%) were aged 75 years or older, 69 499 (79.4%) were non-Hispanic white, and 48 472 (55.3%) were female. Among the total survivors, 24 423 (27.9%) people died within 1 year of discharge, with a median (interquartile range) survival time of 119 (51-220) days. Among these decedents, 16 684 (68.2%) were hospitalized in the last 30 days of life, 6560 (26.8%) died in an acute care hospital, and 12 573 (51.4%) were enrolled in hospice, with 5729 (45.6%) using hospice for 7 or fewer days. Several factors were associated with 1-year mortality, including a cancer diagnosis (odds ratio [OR], 3.66; 95% CI, 3.50-3.83; P < .001), multiple dependencies of activities of daily living or instrumental activities of daily living (OR, 2.80; 95% CI, 2.57-3.05; P < .001), and an overall poor health status (OR, 2.21; 95% CI, 2.01-2.44; P < .001) documented on home health assessment. Among the decedents, cancer was associated with hospice use (OR, 2.25; 95% CI, 2.11-2.41; P < .001), patients aged 85 years or older (OR, 1.49; 95% CI, 1.37-1.61; P < .001), and living in an assisted living setting (OR, 1.93; 95% CI, 1.69-2.19; P < .001).

Conclusions and relevance: The findings of this study suggest that death within 1 year after sepsis discharge may be common among Medicare beneficiaries discharged to home health care. Although 1 in 2 decedents used hospice, aggressive care near the end of life and late hospice referral were common. Readily identifiable risk factors suggest opportunities to target efforts to improve palliative and end-of-life care among high-risk sepsis survivors.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Murtaugh and Ms Barrón reported receiving grants from the National Institute of Nursing Research (NINR) of the National Institutes of Health (NIH) during the conduct of the study. Dr Deb reported receiving grants from the NIH during the conduct of the study. Dr Mikkelsen reported receiving grants from the NINR of the NIH during the conduct of the study and consulting fees from the Hospital and Healthsystem Association of Pennsylvania outside the submitted work. No other disclosures were reported.

Figures

Figure 1.
Figure 1.. Flow Diagram for Identification of Cohort of Medicare Sepsis Survivors Discharged to Home Health Care
Figure 2.
Figure 2.. One-Year Survival Among 87 581 Patients After Sepsis Discharge to Home Health Care
See this image and copyright information in PMC

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