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Editorial
. 2020 May 15;201(10):1174-1176.
doi: 10.1164/rccm.202002-0277ED.

The Wnt Signaling Pathway and the Development of Bronchopulmonary Dysplasia

Krithika Lingappan  1 , Rashmin C Savani  2
Affiliations
Editorial

The Wnt Signaling Pathway and the Development of Bronchopulmonary Dysplasia

Krithika Lingappan et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
NFκB (nuclear factor-κB) drives the transcription of pro-IL1β, and the NLRP3 inflammasome controls the formation of mature IL1β. IL1β increases the expression of Wnt5a in the mesenchyme, leading to increased Wnt signaling in type 2 alveolar epithelial cells. Wnt5a expression can also be increased by several other signaling pathways such as Hedgehog, TGFβ, and Notch. The mechanisms leading to impaired alveolar development secondary to increased Wnt signaling in the pulmonary mesenchyme and type 2 alveolar epithelial cells still need to be elucidated.
See this image and copyright information in PMC

Comment on

  • Hyperoxia Injury in the Developing Lung Is Mediated by Mesenchymal Expression of Wnt5A.
    Sucre JMS, Vickers KC, Benjamin JT, Plosa EJ, Jetter CS, Cutrone A, Ransom M, Anderson Z, Sheng Q, Fensterheim BA, Ambalavanan N, Millis B, Lee E, Zijlstra A, Königshoff M, Blackwell TS, Guttentag SH. Sucre JMS, et al. Am J Respir Crit Care Med. 2020 May 15;201(10):1249-1262. doi: 10.1164/rccm.201908-1513OC. Am J Respir Crit Care Med. 2020. PMID: 32023086 Free PMC article.

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