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. 2020 Feb 26;15(2):e0226936.
doi: 10.1371/journal.pone.0226936. eCollection 2020.

Seasonality of ventricular fibrillation at first myocardial infarction and association with viral exposure

Charlotte Glinge  1   2 , Thomas Engstrøm  1   3 , Sofie E Midgley  4 , Michael W T Tanck  5 , Jeppe Ekstrand Halkjær Madsen  1   6 , Frants Pedersen  1 , Mia Ravn Jacobsen  1 , Elisabeth M Lodder  2 , Nour R Al-Hussainy  1 , Niels Kjær Stampe  1 , Ramona Trebbien  4 , Lars Køber  1 , Thomas Gerds  6 , Christian Torp-Pedersen  7   8 , Thea K Fischer  4   9 , Connie R Bezzina  2 , Jacob Tfelt-Hansen  1   10 , Reza Jabbari  1   11
Affiliations

Seasonality of ventricular fibrillation at first myocardial infarction and association with viral exposure

Charlotte Glinge et al. PLoS One. .

Erratum in

Abstract

Aims: To investigate seasonality and association of increased enterovirus and influenza activity in the community with ventricular fibrillation (VF) risk during first ST-elevation myocardial infarction (STEMI).

Methods: This study comprised all consecutive patients with first STEMI (n = 4,659; aged 18-80 years) admitted to the invasive catheterization laboratory between 2010-2016, at Copenhagen University Hospital, Rigshospitalet, covering eastern Denmark (2.6 million inhabitants, 45% of the Danish population). Hospital admission, prescription, and vital status data were assessed using Danish nationwide registries. We utilized monthly/weekly surveillance data for enterovirus and influenza from the Danish National Microbiology Database (2010-2016) that receives copies of laboratory tests from all Danish departments of clinical microbiology.

Results: Of the 4,659 consecutively enrolled STEMI patients, 581 (12%) had VF before primary percutaneous coronary intervention. In a subset (n = 807), we found that VF patients experienced more generalized fatigue and flu-like symptoms within 7 days before STEMI compared with the patients without VF (OR 3.39, 95% CI 1.76-6.54). During the study period, 2,704 individuals were diagnosed with enterovirus and 19,742 with influenza. No significant association between enterovirus and VF (OR 1.00, 95% CI 0.99-1.02), influenza and VF (OR 1.00, 95% CI 1.00-1.00), or week number and VF (p-value 0.94 for enterovirus and 0.89 for influenza) was found.

Conclusion: We found no clear seasonality of VF during first STEMI. Even though VF patients had experienced more generalized fatigue and flu-like symptoms within 7 days before STEMI compared with patients without VF, no relationship was found between enterovirus or influenza exposure and occurrence of VF.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Study population selection and data collection.
Fig 2
Fig 2. Number of influenza, enterovirus (EV) and ventricular fibrillation (VF) cases per week and month by year.
Fig 3
Fig 3. Odds ratio for ventricular fibrillation during first ST-elevation myocardial infarction.
See this image and copyright information in PMC

References

    1. Deo R, Albert CM. Epidemiology and genetics of sudden cardiac death. Circulation 2012;125:620–637. 10.1161/CIRCULATIONAHA.111.023838 - DOI - PMC - PubMed
    1. Wellens HJJ, Schwartz PJ, Lindemans FW, Buxton AE, Goldberger JJ, Hohnloser SH, et al. Risk stratification for sudden cardiac death: current status and challenges for the future. Eur Heart J 2014;35:1642–1651. 10.1093/eurheartj/ehu176 - DOI - PMC - PubMed
    1. Priori SG, Blomström-Lundqvist C. 2015 European Society of Cardiology Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death summarized by co-chairs. Eur Heart J 2015;36:2757–2759. 10.1093/eurheartj/ehv445 - DOI - PubMed
    1. Chugh SS. Early identification of risk factors for sudden cardiac death. Nat Rev Cardiol 2010;7:318–326. 10.1038/nrcardio.2010.52 - DOI - PMC - PubMed
    1. Arking DE, Chugh SS, Chakravarti A, Spooner PM. Genomics in sudden cardiac death. Circ Res 2004;94:712–723. 10.1161/01.RES.0000123861.16082.95 - DOI - PubMed

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