Premortem Tumor Stress in Radioimmunotherapy

Ignacio Melero¹, Maite Alvarez², Luna Minute², Pedro Berraondo³

Affiliations

¹ Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain; Navarra Institute for Health Research (IDISNA), Pamplona, Spain; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain; Department of Oncology, Clínica Universidad de Navarra, Pamplona, Spain. Electronic address: imelero@unav.es.
² Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain; Navarra Institute for Health Research (IDISNA), Pamplona, Spain.
³ Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain; Navarra Institute for Health Research (IDISNA), Pamplona, Spain; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.

PMID: 32101719
DOI: 10.1016/j.trecan.2020.01.001

Comment

Premortem Tumor Stress in Radioimmunotherapy

Ignacio Melero et al. Trends Cancer. 2020 Mar.

. 2020 Mar;6(3):173-174.

doi: 10.1016/j.trecan.2020.01.001. Epub 2020 Jan 27.

Authors

Ignacio Melero¹, Maite Alvarez², Luna Minute², Pedro Berraondo³

Affiliations

¹ Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain; Navarra Institute for Health Research (IDISNA), Pamplona, Spain; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain; Department of Oncology, Clínica Universidad de Navarra, Pamplona, Spain. Electronic address: imelero@unav.es.
² Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain; Navarra Institute for Health Research (IDISNA), Pamplona, Spain.
³ Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain; Navarra Institute for Health Research (IDISNA), Pamplona, Spain; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.

PMID: 32101719
DOI: 10.1016/j.trecan.2020.01.001

Abstract

Recent investigations (Rodriguez-Ruiz et al.) have established the counterintuitive idea that delaying apoptosis upon tumor irradiation by caspase 3 inhibition in tumor cells raises the immunogenicity of dying malignant cells.

Keywords: caspase 3 inhibitor; immunogenic cell death; radiotherapy.

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Lung transplantation: a review of the optimal strategies for referral and patient selection.
Mitchell AB, Glanville AR. Mitchell AB, et al. Ther Adv Respir Dis. 2019 Jan-Dec;13:1753466619880078. doi: 10.1177/1753466619880078. Ther Adv Respir Dis. 2019. PMID: 31588850 Free PMC article. Review.
Apoptotic caspases inhibit abscopal responses to radiation and identify a new prognostic biomarker for breast cancer patients.
Rodriguez-Ruiz ME, Buqué A, Hensler M, Chen J, Bloy N, Petroni G, Sato A, Yamazaki T, Fucikova J, Galluzzi L. Rodriguez-Ruiz ME, et al. Oncoimmunology. 2019 Aug 26;8(11):e1655964. doi: 10.1080/2162402X.2019.1655964. eCollection 2019. Oncoimmunology. 2019. PMID: 31646105 Free PMC article.

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Premortem Tumor Stress in Radioimmunotherapy

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Premortem Tumor Stress in Radioimmunotherapy

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Medical

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