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. 2020 Jul;161(7):1420-1424.
doi: 10.1097/j.pain.0000000000001843.

Improving pain assessment in mice and rats with advanced videography and computational approaches

Nathan T Fried  1 , Alexander Chamessian  2   3   4 , Mark J Zylka  5 , Ishmail Abdus-Saboor  6
Affiliations

Improving pain assessment in mice and rats with advanced videography and computational approaches

Nathan T Fried et al. Pain. 2020 Jul.
No abstract available

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Conflict of interest statement

The authors have no conflicts of interest to declare.

Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article.

Figures

Figure 1.
Figure 1.
High-speed videography reveals differences in paw movements to innocuous vs noxious stimuli. Red paw trajectory patterns display path of stimulated paw from lift to return using automated paw tracking approaches. Orbital (eye) tightening, a MGS action unit indicative of pain, is also visible after pinprick (B), but not in response to an innocuous stimulus (A).
See this image and copyright information in PMC

References

    1. Abdus-Saboor I, Fried NT, Lay M, Burdge J, Swanson K, Fischer R, Jones J, Dong P, Cai W, Guo X, Tao YX, Bethea J, Ma M, Dong X, Ding L, Luo W. Development of a mouse pain scale using sub-second behavioral mapping and statistical modeling. Cell Rep 2019;28:1623–34.e1624. - PMC - PubMed
    1. Andre E, Conquet F, Steinmayr M, Stratton SC, Porciatti V, Becker-Andre M. Disruption of retinoid-related orphan receptor beta changes circadian behavior, causes retinal degeneration and leads to vacillans phenotype in mice. EMBO J 1998;17:3867–77. - PMC - PubMed
    1. Arcourt A, Gorham L, Dhandapani R, Prato V, Taberner FJ, Wende H, Gangadharan V, Birchmeier C, Heppenstall PA, Lechner SG. Touch receptor-derived sensory information alleviates acute pain signaling and fine-tunes nociceptive reflex coordination. Neuron 2017;93:179–93. - PubMed
    1. Beaudry H, Daou I, Ase AR, Ribeiro-da-Silva A, Seguela P. Distinct behavioral responses evoked by selective optogenetic stimulation of the major TRPV1+ and MrgD+ subsets of C-fibers. PAIN 2017;158:2329–39. - PubMed
    1. Berge OG. Predictive validity of behavioural animal models for chronic pain. Br J Pharmacol 2011;164:1195–206. - PMC - PubMed