Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Feb 1;21(2):281-287.
doi: 10.31557/APJCP.2020.21.2.281.

LncRNAs as Potential Therapeutic Targets in Thyroid Cancer

Zeeshan Javed  1 , Faiez Ahmed Shah  2 , Sadegh Rajabi  3 , Qamar Raza  4 , Zaheer Iqbal  5 , Mukhtar Ullah  1 , Touqeer Ahmad  2 , Bahare Salehi  6 , Mehdi Sharifi-Rad  7 , Raffaele Pezzani  8   9 , Farooq Yaqoob  5 , Haleema Sadia  1 , Marcello Iriti  10 , Javad Sharifi-Rad  11 , William C Cho  12
Affiliations
Review

LncRNAs as Potential Therapeutic Targets in Thyroid Cancer

Zeeshan Javed et al. Asian Pac J Cancer Prev. .

Abstract

Thyroid cancer (TC) is the most common cancer of endocrine system. TC can be subdivided into 4 different entities, papillary, follicular, medullary and anaplastic thyroid cancer. Among them, anaplastic thyroid cancer has the poorest prognosis. Exploring new therapeutic approach may entail favorable prediction as well as increasing overall survival rate of patients. Long non-coding RNAs (lncRNAs), have vast implications in different cancer types. Although they are not transcribed into proteins, they can act as a harness in regulating a plethora of biological functions. They have been implicated in a decisive role in gene expression via modulation of both coding and non-coding RNAs. This article discuss the multi-facet role of lncRNA in thyroid cancer biology.<br />.

Keywords: Diagnosis; Thyroid cancer; genetic alterations; lncRNA; treatment.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Functions and Mechanism of Action of lncRNAs in Different Biological Processes such as Transcription, Post-Transcription and Epigenetic Regulation
Figure 2
Figure 2
Functions of lncRNAs in the Pathogenesis and Their Potential Clinical Applications or Therapeutic Strategies in TC. LncRNAs play a vital role in Cell Migration, Metastasis, Cell Proliferation, Apoptosis, Cell cycle process and Invasion. Arrows indicate the inhibition and activation of these mechanisms by lncRNAs and how these lncRNAs can be exploited for the therapeutic effects
See this image and copyright information in PMC

References

    1. Aboelnaga EM, Ahmed RA. Difference between papillary and follicular thyroid carcinoma outcomes: an experience from Egyptian institution. Cancer Biol Med. 2015;12:53. - PMC - PubMed
    1. Alok Pathak K, Leslie WD, Klonisch TC, et al. The changing face of thyroid cancer in a population-based cohort. Cancer Med. 2013;2:537–44. - PMC - PubMed
    1. Bhan A, Mosella M, Singer MC, et al. DNA methylation signature associated with risk of recurrence in papillary thyroid carcinoma. Thyroid. 2018;28:A24.
    1. Chu R, Van Hasselt A, Vlantis AC, et al. The cross-talk between estrogen receptor and peroxisome proliferator-activated receptor gamma in thyroid cancer. Cancer. 2014;120:142–53. - PubMed
    1. Covach A, Patel S, Hardin H, et al. Phosphorylated Mechanistic target of Rapamycin (p-mTOR) and Noncoding RNA expression in follicular and Hürthle cell thyroid neoplasm. Endocr Pathol. 2017;28:207–12. - PubMed

MeSH terms