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. 2020 Mar;22(1):72-79.
doi: 10.51893/2020.1.sr1.

Nitric oxide: a new role in intensive care

Alexandra Lee  1 , Warwick Butt  2
Affiliations

Nitric oxide: a new role in intensive care

Alexandra Lee et al. Crit Care Resusc. 2020 Mar.

Abstract

Inhaled nitric oxide has been used for 30 years to improve oxygenation and decrease pulmonary vascular resistance. In the past 15 years, there has been increased understanding of the role of endogenous nitric oxide on cell surface receptors, mitochondria, and intracellular processes involving calcium and superoxide radicals. This has led to several animal and human experiments revealing a potential role for administered nitric oxide or nitric oxide donors in patients with systemic inflammatory response syndrome or ischaemia-reperfusion injury, and in patients for whom exposure of blood to artificial surfaces has occurred.

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Conflict of interest statement

Alexandra Lee was funded by the Stuart Green Memorial Trust and Sands Cox Society, but there was no funding for this article. The authors and researchers who assisted in developing this article had full access to all the data used (including statistical reports and tables), and can take responsibility for the integrity of the data and the accuracy of the data analysis.

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