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. 2020 Feb 26;10(1):3445.
doi: 10.1038/s41598-020-60541-1.

Green Synthesis of Zinc Oxide Nanoparticles Using Aqueous Extract of Deverra tortuosa and their Cytotoxic Activities

Yasser A Selim  1 , Maha A Azb  2 , Islam Ragab  3 , Mohamed H M Abd El-Azim  4
Affiliations

Green Synthesis of Zinc Oxide Nanoparticles Using Aqueous Extract of Deverra tortuosa and their Cytotoxic Activities

Yasser A Selim et al. Sci Rep. .

Abstract

In recent years, there is a growing interest towards the green synthesis of metal nanoparticles, particularly from plants; however, yet no published study on the synthesis of ZnO.NPs using the Deverra tortuosa extract. Through this study, zinc oxide nanoparticles (ZnO.NPs) have been synthesized based on using the environmentally benign extract of the aerial parts of D. tortuosa as a reducing and capping agent. ZnO.NPs synthesis was confirmed using UV-Visible (UV-Vis) spectroscopy, Fourier Transform Infrared Spectroscopy (FTIR), X-ray Diffraction (XRD) and High Resolution-Transmission Electron Microscope (HR-TEM). The qualitative and quantitative analyses of plant extract were done. The potential anticancer activity was in vitro investigated against two cancer cell lines (human colon adenocarcinoma "Caco-2" and human lung adenocarcinoma "A549") compared to their activities on the human lung fibroblast cell line (WI38) using the MTT assay. Both the aqueous extract and ZnO.NPs showed a remarkable selective cytotoxicity against the two examined cancer cell lines.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
HPLC chromatogram: (A) Standard mixture of polyphenolic compounds; (B) Aqueous extract of D. tortuosa aerial parts.
Figure 2
Figure 2
Chemical structures of polyphenolic compounds of D. tortuosa aerial parts.
Figure 3
Figure 3
X-ray diffraction pattern of ZnO.NPs.
Figure 4
Figure 4
HR-TEM micrograph of ZnO.NPs.
Figure 5
Figure 5
IC50 of D. tortuosa aqueous extract, ZnO.NPs and Doxorubicin on the Caco-2 and A549 cancer cells compared to WI38 normal cells.
See this image and copyright information in PMC

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