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Comment
. 2020 Jun;109(6):1278-1279.
doi: 10.1111/apa.15190. Epub 2020 Feb 26.

Does topiramate in addition to therapeutic hypothermia reduce seizure burden in infants with hypoxic-ischaemic encephalopathy compared to therapeutic hypothermia alone?

Kathleen E Hannan  1 , Megan J Kirkley  1
Affiliations
Comment

Does topiramate in addition to therapeutic hypothermia reduce seizure burden in infants with hypoxic-ischaemic encephalopathy compared to therapeutic hypothermia alone?

Kathleen E Hannan et al. Acta Paediatr. 2020 Jun.
No abstract available

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Comment on

  • Topiramate plus Cooling for Hypoxic-Ischemic Encephalopathy: A Randomized, Controlled, Multicenter, Double-Blinded Trial.
    Nuñez-Ramiro A, Benavente-Fernández I, Valverde E, Cordeiro M, Blanco D, Boix H, Cabañas F, Chaffanel M, Fernández-Colomer B, Fernández-Lorenzo JR, Kuligowski J, Loureiro B, Moral-Pumarega MT, Pavón A, Sánchez-Illana A, Tofé I, Hervás D, García-Robles A, Parra-Llorca A, Cernada M, Martinez-Rodilla J, Lorente-Pozo S, Llorens R, Marqués R, Vento M; on behalf of the Hypotop Study Group. Nuñez-Ramiro A, et al. Neonatology. 2019;116(1):76-84. doi: 10.1159/000499084. Epub 2019 May 15. Neonatology. 2019. PMID: 31091527 Clinical Trial.

References

REFERENCES

    1. Gluckman PD, Wyatt JS, Azzopardi D, et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial. Lancet. 2005;365:663-670.
    1. Jacobs S, Berg M, Hunt R, Tarnow-Mordi W, Inder T, Davis P. Cooling for newborns with hypoxic ischaemic encephalopathy (Review). Cochrane Database Syst Rev. 2013;CD003311.
    1. Kharoshankaya L, Stevenson NJ, Livingstone V, et al. Seizure burden and neurodevelopmental outcome in neonates with hypoxic-ischemic encephalopathy. Dev Med Child Neurol. 2016;58(12):1242-1248.
    1. Shellhaas RA, Soaita AI, Clancy RR. Sensitivity of amplitude-integrated electroencephalography for neonatal seizure detection. Pediatrics. 2007;120(4):770-777.
    1. Tyson JE, Mcdonald SA, Donovan EF, et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med. 2005;353:1574-1584.

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