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Review
. 2019 Mar;14(2):130-143.
doi: 10.1016/j.ajps.2018.04.004. Epub 2018 May 10.

Electrospun nanofibers as a wound dressing for treating diabetic foot ulcer

Yan Liu  1 , Shiya Zhou  2 , Yanlin Gao  2 , Yinglei Zhai  3
Affiliations
Review

Electrospun nanofibers as a wound dressing for treating diabetic foot ulcer

Yan Liu et al. Asian J Pharm Sci. 2019 Mar.

Abstract

Diabetes is one of the most prevalent diseases in the world with high-mortality and complex complications including diabetic foot ulcer (DFU). It has been reported that the difficulties in repairing the wound related to DFU has much relationship with the wound infection, change of inflammatory responses, lack of extracellular matrix (ECM), and the failure of angiogenesis. Following the development of medical materials and pharmaceutical technology, nanofibers has been developed by electrospinning with huge porosity, excellent humidity absorption, a better oxygen exchange rate, and some antibacterial activities. That is to say, as a potential material, nanofibers must be a wonderful candidate for the DFU treatment with so many benefits. Careful selection of polymers from natural resource and synthetic resource can widen the nanofibrous application. Popular methods applied for the nanofibrous fabrication consist of uniaxial electrospinning and coaxial electrospinning. Furthermore, nanofibers loading chemical, biochemical active pharmaceutical ingredient (API) or even stem cells can be wonderful dosage forms for the treatment of DFU. This review summarizes the present techniques applied in the fabrication of nanofibrous dressing (ND) that utilizes a variety of materials and active agents to offer a better health care for the patients suffering from DFU.

Keywords: Coaxial electrospinning; Diabetic foot ulcer; Nanofibers; Nanofibrous dressing; Uniaxial electrospinning.

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Figures

Image, graphical abstract
Graphical abstract
Fig 1
Fig. 1
(A) PLA fibers electrospun by portable electrospinning device on hand; (B) the final appearance of a homogenous ND; (C) removing the ND with a tweezer from skin (Reproduced with permission from .). Copyright 2015, The Royal Society of Chemistry.
Fig 2
Fig. 2
(A) Schematic apparatus used for the uniaxial electrospinning and (B) the coaxial electrospinning.
Fig 3
Fig. 3
Field-emission electron micrographs of uniaxial nanofibers made by PCL-gelatin at (A) 50 μm and (B) 20 μm. Reproduced with permission from . Copyright 2007, Elsevier.
Fig 4
Fig. 4
TEM images of coaxial nanofibers made by PEO and chitosan. (A) Concentric and (B) eccentric core and shell structures (Reproduced with permission from .). Copyright 2012, American Chemical Society.
Fig 5
Fig. 5
Photographs of the wound closure of diabetic rats on days 0, 3, 7, 14, (A) collagen/PLGA with glucophage-loaded group, (B) pure collagen/PLGA group, (C) gauze sponge group (Reproduced with permission from .). Copyright 2015, Elsevier.
See this image and copyright information in PMC

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