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Review
. 2020 Mar 1;161(3):bqaa014.
doi: 10.1210/endocr/bqaa014.

Impact of Exogenous Testosterone on Reproduction in Transgender Men

Molly B Moravek  1   2 , Hadrian M Kinnear  3   4 , Jenny George  1 , Jourdin Batchelor  5 , Ariella Shikanov  1   3   6 , Vasantha Padmanabhan  1   7 , John F Randolph  1
Affiliations
Review

Impact of Exogenous Testosterone on Reproduction in Transgender Men

Molly B Moravek et al. Endocrinology. .

Abstract

Studies show that a subset of transgender men desire children; however, there is a paucity of literature on the effect of gender-affirming testosterone therapy on reproductive function. In this manuscript, we will review the process of gender-affirming hormone therapy for transgender men and what is known about ovarian and uterine consequences of testosterone exposure in transgender men; draw parallels with existing animal models of androgen exposure; summarize the existing literature on parenting experiences and desires in transgender people; discuss considerations for assisted reproductive technologies and fertility preservation; and identify gaps in the literature and opportunities for further research.

Keywords: fertility; gender-affirming hormone therapy; reproduction; transgender men.

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References

    1. Flores AR, Herman JL, Gates GJ, Brown TNT.. How Many Adults Identify as Transgender in the United States? Los Angeles, CA: The Williams Institute; 2016.
    1. Crissman HP, Berger MB, Graham LF, Dalton VK. Transgender demographics: a household probability sample of US adults, 2014. Am J Public Health. 2017;107(2):213–215. - PMC - PubMed
    1. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th ed. American Psychiatric Association; 2013. American Psychiatric Association website. https://psychiatryonline.org/doi/book/10.1176/appi.books.9780890425596. Accessed August 18, 2018. - DOI
    1. Coleman E, Bockting W, Botzer M, et al. . Standards of care for the health of transsexual, transgender, and gender-nonconforming people, version 7. Int J Transgend. 2012;13(4):165–232.
    1. Ethics Committee of the American Society for Reproductive Medicine. Access to fertility services by transgender persons: an Ethics Committee opinion. Fertil Steril. 2015;104(5):1111–1115. - PubMed

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