Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Feb 27;17(2):e1003059.
doi: 10.1371/journal.pmed.1003059. eCollection 2020 Feb.

Advances in clinical trial design: Weaving tomorrow's TB treatments

Christian Lienhardt  1 , Andrew Nunn  2 , Richard Chaisson  3 , Andrew A Vernon  4 , Matteo Zignol  5 , Payam Nahid  6 , Eric Delaporte  1 , Tereza Kasaeva  5
Affiliations
Review

Advances in clinical trial design: Weaving tomorrow's TB treatments

Christian Lienhardt et al. PLoS Med. .

Abstract

Christian Lienhardt and co-authors discuss the conclusions of the PLOS Medicine Collection on advances in clinical trial design for development of new tuberculosis treatments.

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. The successive clinical trial phases in human development for TB drugs/regimens [8].
TB, tuberculosis.
See this image and copyright information in PMC

References

    1. Fox W, Mitchison DA. State of the Art. Short-course chemotherapy for pulmonary tuberculosis. Am Rev Respir Dis. 1975; 111: 325–353. 10.1164/arrd.1975.111.3.325 - DOI - PubMed
    1. Fox W, Ellard GA, Mitchison DA. Studies on the treatment of tuberculosis undertaken by the British Medical Research Council Tuberculosis Units, 1946–1986, with relevant subsequent publications. Int J Tuberc Lung Dis. 1999; 3(Suppl):S231–S279. - PubMed
    1. Tiberi S, du Plessis N, Walzl G, Vjecha MJ, Rao M, Ntoumi F, et al. Tuberculosis: progress and advances in development of new drugs, treatment regimens, and host-directed therapies. Lancet Infect Dis. 2018;18: e183–98 - PubMed
    1. Working Group on New Drugs [Internet]. New York: The Working Group for New TB Drugs; c2016. [cited 2019 Sept 29] Available from: https://www.newtbdrugs.org/pipeline/clinical
    1. Lienhardt C, Kraigsley AM, Sizemore CF. Driving the Way to Tuberculosis Elimination: The Essential Role of Fundamental Research. Clin Infect Dis. 2016;63(3):370–5. 10.1093/cid/ciw250 - DOI - PMC - PubMed

MeSH terms

Substances