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Review
. 2020 Feb 25;21(5):1578.
doi: 10.3390/ijms21051578.

Biomarkers of Liver Injury during Transplantation in an Era of Machine Perfusion

Ricky H Bhogal  1   2   3 , Darius F Mirza  1   2   4 , Simon C Afford  1   2 , Hynek Mergental  1   2   4
Affiliations
Review

Biomarkers of Liver Injury during Transplantation in an Era of Machine Perfusion

Ricky H Bhogal et al. Int J Mol Sci. .

Abstract

Liver ischaemia-reperfusion injury (IRI) is an intrinsic part of the transplantation process and damages the parenchymal cells of the liver including hepatocytes, endothelial cells and cholangiocytes. Many biomarkers of IRI have been described over the past two decades that have attempted to quantify the extent of IRI involving different hepatic cellular compartments, with the aim to allow clinicians to predict the suitability of donor livers for transplantation. The advent of machine perfusion has added an additional layer of complexity to this field and has forced researchers to re-evaluate the utility of IRI biomarkers in different machine preservation techniques. In this review, we summarise the current understanding of liver IRI biomarkers and discuss them in the context of machine perfusion.

Keywords: biomarkers; ischaemia–reperfusion injury; liver transplantation; machine perfusion.

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Conflict of interest statement

The authors declare no conflict of interest. This paper is based on expertise and independent research supported by the NIHR Birmingham Biomedical Research Centre at the University Hospitals Birmingham NHS Foundation Trust and the University of Birmingham. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health.

Figures

Figure 1
Figure 1
Liver ischaemia reperfusion injury. The scheme demonstrates the multifactorial nature of ischaemia–reperfusion injury (IRI) with multiple processes involved, which ultimately result in liver damage.
See this image and copyright information in PMC

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