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Meta-Analysis
. 2020 Feb 27;18(1):44.
doi: 10.1186/s12957-020-01814-x.

Systematic review and meta-analysis of video-assisted thoracoscopic surgery segmentectomy versus lobectomy for stage I non-small cell lung cancer

Weibiao Zeng  1 , Wenxiong Zhang  1 , Jianyong Zhang  2 , Guangmiao You  1 , Yu'ang Mao  1 , Jianjun Xu  1 , Dongliang Yu  1 , Jinhua Peng  1 , Yiping Wei  3
Affiliations
Meta-Analysis

Systematic review and meta-analysis of video-assisted thoracoscopic surgery segmentectomy versus lobectomy for stage I non-small cell lung cancer

Weibiao Zeng et al. World J Surg Oncol. .

Abstract

Background: Whether video-assisted thoracoscopic surgery (VATS) segmentectomy and VATS lobectomy provide similar perioperative and oncological outcomes in stage I non-small cell lung cancer (NSCLC) is still controversial.

Methods: Meta-analysis of 12 studies comparing outcomes after VATS lobectomy and VATS segmentectomy for stage I NSCLC. Data were analyzed by the RevMan 5.3 software.

Results: Disease-free survival (HR 1.19, 95% CI 0.89 to 1.33, P = 0.39), overall survival (HR 1.11, 95% CI 0.89 to 1.38, P = 0.36), postoperative complications (OR = 1.10, 95% CI 0.69 to 1.75, P = 0.7), intraoperative blood loss (MD = 3.87, 95% CI - 10.21 to 17.94, P = 0.59), operative time (MD = 10.89, 95% CI - 13.04 to 34.82, P = 0.37), air leak > 5 days (OR = 1.20, 95% CI 0.66 to 2.17, P = 0.55), and in-hospital mortality (OR = 1.67, 95% CI 0.39 to 7.16, P = 0.49) were comparable between the groups. Postoperative hospital stay (MD = - 0.69, 95% CI - 1.19 to - 0.19, P = 0.007) and number of dissected lymph nodes (MD = - 6.44, 95%CI - 9.49 to - 3.40, P < 0.0001) were significantly lower in VATS segmentectomy patients.

Conclusions: VATS segmentectomy and VATS lobectomy provide similar oncological and perioperative outcomes for stage I NSCLC patients. This systematic review was registered on PROSPERO and can be accessed at http://www.crd.york.ac.uk/PROSPERO/display_record.php?ID = CRD42019133398.

Keywords: Lung cancer; Meta-analysis; NSCLC; VATS segmentectomy.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Flow diagram showing the process of selection of studies
Fig. 2
Fig. 2
Forest plot for disease-free survival of the VATS segmentectomy and VATS lobectomy groups in the studies analyzed
Fig. 3
Fig. 3
Forest plot for overall survival of the VATS segmentectomy and VATS lobectomy groups in the studies analyzed
Fig. 4
Fig. 4
Forest plot for postoperative complications of the VATS segmentectomy and VATS lobectomy groups in the studies analyzed
Fig. 5
Fig. 5
Forest plot for postoperative hospital stay of the VATS segmentectomy and VATS lobectomy groups in the studies analyzed
Fig. 6
Fig. 6
Forest plot for intraoperative blood loss of the VATS segmentectomy and VATS lobectomy groups in the studies analyzed
Fig. 7
Fig. 7
Forest plot for operation time of the VATS segmentectomy and VATS lobectomy groups in the studies analyzed
Fig. 8
Fig. 8
Forest plot for air leak (> 5 days) of the VATS segmentectomy and VATS lobectomy groups in the studies analyzed
Fig. 9
Fig. 9
Forest plot for in-hospital mortality of the VATS segmentectomy and VATS lobectomy groups in the studies analyzed
Fig. 10
Fig. 10
Forest plot for dissected lymph nodes of VATS segmentectomy and VATS lobectomy groups in the studies analyzed
Fig. 11
Fig. 11
Funnel plot for overall survival of the VATS segmentectomy and VATS lobectomy groups in the studies analyzed
See this image and copyright information in PMC

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