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Comment
. 2020 Apr;16(4):185.
doi: 10.1038/s41582-020-0335-5.

APOE*ε4 promotes synucleinopathy

Ian Fyfe  1
Affiliations
Comment

APOE*ε4 promotes synucleinopathy

Ian Fyfe. Nat Rev Neurol. 2020 Apr.
No abstract available

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Comment on

  • APOE4 exacerbates α-synuclein pathology and related toxicity independent of amyloid.
    Zhao N, Attrebi ON, Ren Y, Qiao W, Sonustun B, Martens YA, Meneses AD, Li F, Shue F, Zheng J, Van Ingelgom AJ, Davis MD, Kurti A, Knight JA, Linares C, Chen Y, Delenclos M, Liu CC, Fryer JD, Asmann YW, McLean PJ, Dickson DW, Ross OA, Bu G. Zhao N, et al. Sci Transl Med. 2020 Feb 5;12(529):eaay1809. doi: 10.1126/scitranslmed.aay1809. Sci Transl Med. 2020. PMID: 32024798 Free PMC article.
  • APOE genotype regulates pathology and disease progression in synucleinopathy.
    Davis AA, Inman CE, Wargel ZM, Dube U, Freeberg BM, Galluppi A, Haines JN, Dhavale DD, Miller R, Choudhury FA, Sullivan PM, Cruchaga C, Perlmutter JS, Ulrich JD, Benitez BA, Kotzbauer PT, Holtzman DM. Davis AA, et al. Sci Transl Med. 2020 Feb 5;12(529):eaay3069. doi: 10.1126/scitranslmed.aay3069. Sci Transl Med. 2020. PMID: 32024799 Free PMC article.

References

Original articles
    1. Davis, A. et al. APOE genotype regulates pathology and disease progression in synucleinopathy. Sci. Transl. Med. 12, eaay3069 (2020) - DOI
    1. Zhao, N. et al. APOE4 exacerbates α-synuclein pathology and related toxicity independent of amyloid. Sci. Transl. Med. 12, eaay1809 (2020) - DOI
Related article
    1. Yamazaki, Y. et al. Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies. Nat. Rev. Neurol. 15, 501–518 (2019) - DOI

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