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. 2020 Mar 28;56(25):3613-3616.
doi: 10.1039/d0cc00222d. Epub 2020 Feb 28.

Stabilizing synthetic DNA for long-term data storage with earth alkaline salts

A Xavier Kohll  1 , Philipp L Antkowiak, Weida D Chen, Bichlien H Nguyen, Wendelin J Stark, Luis Ceze, Karin Strauss, Robert N Grass
Affiliations

Stabilizing synthetic DNA for long-term data storage with earth alkaline salts

A Xavier Kohll et al. Chem Commun (Camb). .

Abstract

Rapid aging tests (70 °C, 50% RH) of solid state DNA dried in the presence of various salt formulations, showed the strong stabilizing effect of calcium phosphate, calcium chloride and magnesium chloride, even at high DNA loadings (>20 wt%). A DNA-based digital information storage system utilizing the stabilizing effect of MgCl2 was tested by storing a DNA file, encoding 115 kB of digital data, and the successful readout of the file by sequencing after accelerated aging.

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