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Clinical Trial
. 1977 Mar 5;1(6061):607-10.
doi: 10.1136/bmj.1.6061.607.

Metronidazole in prevention and treatment of bacteroides infections in elective colonic surgery

A T Willis, I R Ferguson, P H Jones, K D Phillips, P V Tearle, R V Fiddian, D F Graham, D H Harland, D F Hughes, D Knight, W M Mee, N Pashby, R L Rothwell-Jackson, A K Sachdeva, I Sutch, C Kilbey, D Edwards
Clinical Trial

Metronidazole in prevention and treatment of bacteroides infections in elective colonic surgery

A T Willis et al. Br Med J. .

Abstract

A double-blind randomised trial was carried out among 46 patients undergoing elective colonic surgery; 27 patients received prophylactic metronidazole and 19 received placebo. Anaerobic infections did not develop in any of the metronidazole-treated patients, but did develop in 11 (58%) of 19 controls who were subsequently successfully treated with metronidazole.

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References

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    1. Lancet. 1976 Aug 14;2(7981):325-8 - PubMed
    1. Lancet. 1975 Nov 22;2(7943):997-1000 - PubMed
    1. Ann Surg. 1973 Oct;178(4):453-62 - PubMed

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