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. 2020 Jun;45(7):1083-1085.
doi: 10.1038/s41386-020-0639-6. Epub 2020 Feb 28.

Using empirically-derived dimensional phenotypes to accelerate clinical neuroscience: the Hierarchical Taxonomy of Psychopathology (HiTOP) framework

Robert D Latzman #  1 , Colin G DeYoung #  2 ; HITOP NEUROBIOLOGICAL FOUNDATIONS WORKGROUP
Collaborators, Affiliations

Using empirically-derived dimensional phenotypes to accelerate clinical neuroscience: the Hierarchical Taxonomy of Psychopathology (HiTOP) framework

Robert D Latzman et al. Neuropsychopharmacology. 2020 Jun.
No abstract available

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Figures

Fig. 1
Fig. 1. Using the Hierarchical Taxonomy of Psychopathology (HiTOP) in clinical neuroscience.
Recent efforts by an international consortium of researchers have led to HiTOP, a consensual dimensional system (https://medicine.stonybrookmedicine.edu/HITOP/). Step 1 depicts a simplified schematic of the HiTOP working model, from which clinical phenotypes should be selected for study. (HiTOP is a work in progress and will be updated on the basis of new data. Dashed lines indicate provisional elements requiring more study.) Step 2 depicts a sampling design appropriate for HiTOP-based research, which involves sampling from unselected patient populations or the general population, rather than a case-control design, although researchers may wish to oversample participants manifesting or at high risk for the problems of interest. Step 3 depicts testing associations between HiTOP phenotypes and neurobiological variables, ideally examining constructs at multiple levels of the hierarchy, examining constructs from multiple spectra to assess discriminant validity, and using latent variable modeling.
See this image and copyright information in PMC

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