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Case Reports
. 2019 Dec 17;12(3):922-927.
doi: 10.1159/000504929. eCollection 2019 Sep-Dec.

Concomitant BRAF Mutation in Hairy Cell Leukemia and Papillary Thyroid Cancer: Case Report

Shehab F Mohamed  1   1   1 , Feryal Helmi  2   2   2 , Susanna El-Akiki  2   2   2 , Halima El Omri  1   1   1 , Abdulqadir Nashwan  1   1   1 , Mohamed A Yassin  1   1   1
Affiliations
Case Reports

Concomitant BRAF Mutation in Hairy Cell Leukemia and Papillary Thyroid Cancer: Case Report

Shehab F Mohamed et al. Case Rep Oncol. .

Abstract

Hairy cell leukemia (HCL) is rare type of leukemia. This neoplasm is well-known to present with pancytopenia and splenomegaly. HCL is associated with BRAF mutation in 100% of cases. It is also associated with hematological and oncological malignancies such as melanoma and papillary thyroid cancer. Although the association of both cancers (HCL and papillary thyroid cancer) with BRAF mutation is well established in the literature, as far as we know it has not been reported before in the same patient. Here we report 48-year-old male diagnosed with HCL and papillary thyroid cancer and who is BRAF positive in both diagnostic tissues.

Keywords: BRAF; Hairy cell leukemia; Papillary thyroid cancer.

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Conflict of interest statement

The authors have no conflicts to declare.

Figures

Fig. 1
Fig. 1
a PB smear with two inserts of circulating hairy cells with oval to convoluted nucleus, homogeneous to dispersed chromatin, moderately abundant cytoplasm with shaggy hairy outline. b BM aspirate shows many hairy cells. Wright stain. ×1,000. c Examples of hairy cells seen in the BM aspirate; medium to large with pleomorphic nuclear shape; round, oval, cleaved, convoluted or with irregular nuclear contour, mostly with homogenous to dispersed chromatin, many with prominent nucleolus. The cytoplasm is moderately abundant, faintly blue with shaggy or hairy outline.
Fig. 2
Fig. 2
Flow cytometry on BM aspirate revealed 29% monotypic B-cells with heterogeneous high light side scatter with lambda light chain restriction and expressing bright CD19 and CD20 with coexpression of CD25, CD11c, CD103 on a subpopulation, CD123 and FMC7 and positive for CD10. The cells were also positive for CD79b and negative for CD5, CD23 (not shown).
Fig. 3
Fig. 3
a BM biopsy is markedly hypercellular (∼100%). H&E. ×100. b Diffusely infiltrated by widely spaced lymphoid cells, with round, oval or irregular nucleus, many with a moderate amount of cytoplasm with a shaggy irregular outline. Fried egg appearance. c Cells are positive for CD20, DBA44. ×100. Annexin A1 and CD25. ×200.
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References

    1. Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R, et al. The 2016 revision of the World Health Organization (WHO) classification of lymphoid neoplasms. Blood. 2016 May;127((20)):2375–90. - PMC - PubMed
    1. Spedini P, Tajana M, Bergonzi C. Unusual presentation of hairy cell leukemia. Haematologica. 2000;85((5)):548. - PubMed
    1. Venkatesan S, Purohit A, Aggarwal M, Manivannan P, Tyagi S, Mahapatra M, et al. Unusual presentation of hairy cell leukemia: a case series of four clinically unsuspected cases. Indian J Hematol Blood Transfus. 2014;30((Suppl 1)):413–7. - PMC - PubMed
    1. Lembersky BC, Ratain MJ, Golomb HM. Skeletal complications in hairy cell leukemia: diagnosis and therapy. J Clin Oncol. 1988;6((8)):1280–4. - PubMed
    1. Tiacci E, Trifonov V, Schiavoni G, Holmes A, Kern W, Martelli MP, et al. BRAF mutations in hairy-cell leukemia. New Engl J Med. 2011;364((24)):2305–15. - PMC - PubMed

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