Sustained drug retention after paclitaxel-coated balloon angioplasty for superficial femoral artery disease: Follow-up intravascular imaging

Abstract

A 63 year-old woman with claudication underwent endovascular therapy for diffuse stenosis of the right superficial femoral artery in our hospital. We performed paclitaxel-coated balloon angioplasty using the IN.PACT™ Admiral™ and achieved acceptable results. After 42 days, we performed follow-up optical frequency domain imaging for the right superficial femoral artery lesion treated with paclitaxel-coated balloon and observed several high-intensity regions with attenuation on the lumen surface. Sustained drug availability is a notable characteristic of paclitaxel-coated balloon. To the best of our knowledge, this is the first report on the visualization of sustained drug retention on the lumen surface using follow-up optical frequency domain imaging after paclitaxel-coated balloon angioplasty in a human patient with superficial femoral artery disease.

Keywords: Paclitaxel-coated balloon; optical coherence tomography; optical frequency domain imaging; superficial femoral artery disease.

Figure 1.

(a) Preoperative angiography of the right SFA, (b) preoperative intravascular ultrasound findings, (c) final angiography after PCB angioplasty using the IN.PACT™ Admiral™ for right SFA disease and (d) follow-up angiography of the right SFA at 42 days after the procedure.

Figure 2.

(a–c) OFDI images acquired at 42 days after PCB angioplasty using the IN.PACT™ Admiral™ for SFA disease and (d–f) high-power field images. There are several high-intensity regions with attenuation on the lumen surface (arrows).