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Case Reports
. 2020 Feb 16:8:2050313X20907825.
doi: 10.1177/2050313X20907825. eCollection 2020.

Sustained drug retention after paclitaxel-coated balloon angioplasty for superficial femoral artery disease: Follow-up intravascular imaging

Norihiro Kobayashi  1 , Keisuke Hirano  1 , Masahiro Yamawaki  1 , Motoharu Araki  1 , Tsuyoshi Sakai  1 , Yasunari Sakamoto  1 , Shinsuke Mori  1 , Masakazu Tsutsumi  1 , Masahiro Nauchi  1 , Naohiko Sahara  1 , Yohsuke Honda  1 , Kenji Makino  1 , Shigemitsu Shirai  1 , Masafumi Mizusawa  1 , Yuta Sugizaki  1 , Takahide Nakano  1 , Tomoya Fukagawa  1 , Toshihiko Kishida  1 , Yuki Kozai  1 , Yusuke Setonaga  1 , Shutaro Goda  1 , Yoshiaki Ito  1
Affiliations
Case Reports

Sustained drug retention after paclitaxel-coated balloon angioplasty for superficial femoral artery disease: Follow-up intravascular imaging

Norihiro Kobayashi et al. SAGE Open Med Case Rep. .

Abstract

A 63 year-old woman with claudication underwent endovascular therapy for diffuse stenosis of the right superficial femoral artery in our hospital. We performed paclitaxel-coated balloon angioplasty using the IN.PACT™ Admiral™ and achieved acceptable results. After 42 days, we performed follow-up optical frequency domain imaging for the right superficial femoral artery lesion treated with paclitaxel-coated balloon and observed several high-intensity regions with attenuation on the lumen surface. Sustained drug availability is a notable characteristic of paclitaxel-coated balloon. To the best of our knowledge, this is the first report on the visualization of sustained drug retention on the lumen surface using follow-up optical frequency domain imaging after paclitaxel-coated balloon angioplasty in a human patient with superficial femoral artery disease.

Keywords: Paclitaxel-coated balloon; optical coherence tomography; optical frequency domain imaging; superficial femoral artery disease.

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Conflict of interest statement

Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship and/or publication of this article.

Figures

Figure 1.
Figure 1.
(a) Preoperative angiography of the right SFA, (b) preoperative intravascular ultrasound findings, (c) final angiography after PCB angioplasty using the IN.PACT™ Admiral™ for right SFA disease and (d) follow-up angiography of the right SFA at 42 days after the procedure.
Figure 2.
Figure 2.
(a–c) OFDI images acquired at 42 days after PCB angioplasty using the IN.PACT™ Admiral™ for SFA disease and (d–f) high-power field images. There are several high-intensity regions with attenuation on the lumen surface (arrows).
See this image and copyright information in PMC

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