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Case Reports
. 2019 Oct-Dec;45(4):372-382.
doi: 10.12865/CHSJ.45.04.05. Epub 2019 Dec 30.

Combination of Olanzapine Pamoate with Melatonin and Metformin: Quantitative Changes in Rat Adipose Tissue

I C Miron  1 , F Popescu  2 , V Enăchescu  3 , O M Cristea  4 , E C Stoicănescu  5 , E Amzoiu  2 , M Amzoiu  2 , F D Popescu  6
Affiliations
Case Reports

Combination of Olanzapine Pamoate with Melatonin and Metformin: Quantitative Changes in Rat Adipose Tissue

I C Miron et al. Curr Health Sci J. 2019 Oct-Dec.

Abstract

Olanzapine is one of the atypical antipsychotics widely used in the treatment of schizophrenia and has been associated with metabolic changes as adverse effects, including hyperglycemia, dyslipidemia, and weight gain. In a batch of adult female Wistar rats, we studied the prolonged-release intramuscular olanzapine pamoate induced quantitative changes of visceral and subcutaneous adipose tissue. We also assessed the effects of the combinations of olanzapine pamoate with melatonin, metformin, and melatonin plus metformin, administered by gastric gavage. A higher mean weight of the visceral and subcutaneous adipose tissue per animal was noted in the olanzapine pamoate exposed group compared to controls. The association with melatonin, metformin, or the combination of melatonin with metformin attenuated the olanzapine-induced adipose deposit tissue growth. The effect was more pronounced for the combination of olanzapine with melatonin and metformin. Because most of the results were not statistically significant we can deduce that in the chronic experiment, adaptive type modifications of the receptors on which both olanzapine and melatonin act can occur.

Keywords: Adipose tissue; melatonin; metformin; olanzapine pamoate; rats.

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Figures

Figure 1
Figure 1
Comparison between the quantitative differences in grams/female rat of visceral and subcutaneous adipose tissue deposits/animal from the control groups and treated with olanzapine pamoate (A), olanzapine pamoate + melatonin (B), olanzapine pamoate + metformin (C) and olanzapine + melatonin and metformin (D).
Figure 2
Figure 2
Comparison between the quantitative differences in grams/animal of visceral and subcutaneous fat tissue deposits from the groups treated with olanzapine pamoate + melatonin (A), olanzapine pamoate + metformin (B), olanzapine pamoate + melatonin and metformin (C) versus the treated group only with olanzapine pamoate.
See this image and copyright information in PMC

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