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. 2020 Jan 28;9(1):180-186.
doi: 10.4103/jfmpc.jfmpc_908_19. eCollection 2020 Jan.

Antibacterial activity of Syzygium aromaticum (clove) against uropathogens producing ESBL, MBL, and AmpC beta-lactamase: Are we close to getting a new antibacterial agent?

Sameer S Faujdar  1 , Dakshina Bisht  1 , Amisha Sharma  2
Affiliations

Antibacterial activity of Syzygium aromaticum (clove) against uropathogens producing ESBL, MBL, and AmpC beta-lactamase: Are we close to getting a new antibacterial agent?

Sameer S Faujdar et al. J Family Med Prim Care. .

Abstract

Introduction: The present study was done to access the antibacterial activity of clove (Syzygium aromaticum) against extended-spectrum beta-lactamase (ESBL), metallo-beta-lactamase (MBL), and AmpC beta-lactamase-producing gram-negative bacteria causing urinary tract infection.

Methods: A total of 221 gram-negative uropathogens were isolated and screened for beta-lactamase (ESBL, MBL, and AmpC) production and further tested against ethanolic extract of clove (S. aromaticum) for its antibacterial activity.

Results: Clove was effective against all gram-negative isolates but the best antibacterial activity was shown against Proteus species with 19 mm zone of inhibition, 0.39 mg/ml minimum inhibitory concentration (MIC) and 0.19 mg/ml minimum bactericidal concentration (MBC).

Conclusions: Clove extract showed different antibacterial potential against all gram-negative uropathogens. Clove activity for particular strain was found to be similar between isolates producing beta-lactamase and non beta-lactamase.

Keywords: Extended-spectrum β-lactamases; Syzygium aromaticum (clove); and AmpC beta-lactamase; metallo-beta-lactamase; urinary tract infection; uropathogens.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Maximum zone of inhibition (mm) of clove against uropathogens
Figure 2
Figure 2
Average minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values of clove against uropathogens
See this image and copyright information in PMC

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