Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Jan 28;9(1):293-297.
doi: 10.4103/jfmpc.jfmpc_770_19. eCollection 2020 Jan.

Dengue in children and young adults, a cross-sectional study from the western part of Uttar Pradesh

Manoj Kumar  1 , Rajesh Kumar Verma  1 , Suchitra Nirjhar  1 , Monika Singh  1
Affiliations

Dengue in children and young adults, a cross-sectional study from the western part of Uttar Pradesh

Manoj Kumar et al. J Family Med Prim Care. .

Abstract

Background: Dengue has emerged as a major public health problem in India. It presents more aggressively among younger age groups as compared to adults. Therefore, it necessitates the accurate estimation of prevalence in younger age groups.

Materials and method: Of all the 1026 clinically suspected cases of dengue up to the age of 18 years were enrolled in this study and grouped into four age groups (Group I - <0 to 1 year, Group II- 1 to 6 years, Group III- 7 to 12 years, and Group IV- 13 to 18 years). Their blood samples were aseptically collected from different clinical departments and were submitted to the Viral Research and Diagnostic Laboratory (VRDL), Department of Microbiology during the outbreak of 2016-17. Serum was separated and processed for dengue Non Structural Protein 1 antigen (NS1 Ag)and Immunoglobuline M antibody (IgM Ab) enzyme-linked immunosorbent assay (ELISA). All the relevant variables like age, sex, and demographic profile were recorded and statistically analyzed.

Results: A total 295 of the 1026 cases were detected positive for dengue either by NS1 Ag or IgM Ab ELISA. The results show the susceptibility to dengue being increased in the order of age Group I to IV. We analyzed the outbreak of year 2016 and 2017, of these 159/483 (33%) cases and 136/543 (25%) cases, respectively, were found seropositive during these years. The months of September, October, and November are more prone to dengue infection.

Conclusion: Group III and IV were more susceptible to dengue fever (DF). The months of postmonsoon season are more favorable for spread of dengue among different age groups of the population.

Keywords: Dengue; IgM Ab; NS1 Ag.

PubMed Disclaimer

Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Distribution of age group wise NS1 and IgM seropositive cases at X-axis and total cases at Y-axis (N = 295)
See this image and copyright information in PMC

References

    1. World Health Organization and the Special Programme for Research and Training in Tropical diseases (TD. Dengue: Guidelines for diagnosis, treatment, prevention, and control”. 2009. [accessed on April 11, 2019]. Available from: http://www.who.int/mediacentre/factsheets/fs117/en/ - PubMed
    1. Suleman M, Lee HW, Zaidi SS, Alam MM, Nisar N, Aamir UB, et al. Preliminary seroepidemiological survey of dengue infections in Pakistan, 2009-2014. Infect Dis Poverty. 2017;6:48. - PMC - PubMed
    1. National Vector Born Disease Control Programme, Director General of Health Services. Ministry of Health and Family welfare. Dengue Cases and Deaths in the Country since 2010. [Last accessed on 2018 Apr 11]. Available from: http://nvbdcp.gov.in/den-cd.html .
    1. Dhooria G, Bhat D, Bains H. Clinical profile and outcome in children of dengue hemorrhagic fever in North India. Iran J Pediatr. 2008;18:222–8.
    1. Murhekar MV, Kamaraj P, Kumar MS, Khan SA, Allam RR, Barde P, et al. Burden of dengue infection in India, 2017: A cross-sectional population based serosurvey. Lancet Glob Health. 2019;7:1063–73. - PubMed