Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2020 Feb 28;24(1):69.
doi: 10.1186/s13054-020-2794-x.

Added value of serial bio-adrenomedullin measurement in addition to lactate for the prognosis of septic patients admitted to ICU

Alice Blet  1   2 , Charles de Roquetaillade  1   2 , Oliver Hartmann  3 , Joachim Struck  3 , Alexandre Mebazaa  1   2 , Benjamin Glenn Chousterman  4   5 ; Adrenoss-1 study investigators
Collaborators, Affiliations
Comment

Added value of serial bio-adrenomedullin measurement in addition to lactate for the prognosis of septic patients admitted to ICU

Alice Blet et al. Crit Care. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

AM has received speaker’s honoraria from Novartis, Orion, and Servier and fees as a member of the advisory board and/or steering committee from Cardiorentis, Adrenomed, sphingotec, Sanofi, Roche, Abbott, and Bristol-Myers Squibb. EG has received consulting fees from Adrenomed, Roche Diagnostics, and Magnisense and lecture fees from Edwards Lifesciences. OH and JS are employees of sphingotec GmbH, the company that developed and holds patent rights in the bio-ADM assay. BC received fees as a member of an advisory board from Roche Diagnostics. The other authors declare that there are no competing interests.

Figures

Fig. 1
Fig. 1
Impact of 24 h lactate and bio-ADM values in patients with elevated lactate level at admission. The green curve in the left KM-plot illustrates data from 75 patients with 5 events, the red curve 70 patients with 18 events. The green curve in the right KM-plot illustrates data from 28 patients with 4 events, the red curve 96 patients with 48 events. Of note, differences in numbers between admission (n = 328) and 24 h (n = 269) is related to initial mortality
See this image and copyright information in PMC

Comment on

References

    1. Fleischmann C, Scherag A, Adhikari NK, Hartog CS, Tsaganos T, Schlattmann P, et al. Assessment of global incidence and mortality of hospital-treated sepsis. Current estimates and limitations. Am J Respir Crit Care Med. 2016;193(3):259–272. doi: 10.1164/rccm.201504-0781OC. - DOI - PubMed
    1. Levy MM, Evans LE, Rhodes A. The Surviving Sepsis Campaign Bundle: 2018 update. Crit Care Med. 2018;46(6):997–1000. doi: 10.1097/CCM.0000000000003119. - DOI - PubMed
    1. Hernandez G, Bellomo R, Bakker J. The ten pitfalls of lactate clearance in sepsis. Intensive Care Med. 2019;45(1):82–85. doi: 10.1007/s00134-018-5213-x. - DOI - PMC - PubMed
    1. Vincent JL, Quintairos ESA, Couto L, Jr, Taccone FS. The value of blood lactate kinetics in critically ill patients: a systematic review. Crit Care. 2016;20(1):257. doi: 10.1186/s13054-016-1403-5. - DOI - PMC - PubMed
    1. Mebazaa A, Geven C, Hollinger A, Wittebole X, Chousterman BG, Blet A, et al. Circulating adrenomedullin estimates survival and reversibility of organ failure in sepsis: the prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock-1 (AdrenOSS-1) study. Crit Care. 2018;22(1):354. doi: 10.1186/s13054-018-2243-2. - DOI - PMC - PubMed

LinkOut - more resources