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. 1988 Aug;8(8):3415-22.
doi: 10.1128/mcb.8.8.3415-3422.1988.

Developmental expression of transforming growth factors alpha and beta in mouse fetus

J N Wilcox  1 , R Derynck
Affiliations

Developmental expression of transforming growth factors alpha and beta in mouse fetus

J N Wilcox et al. Mol Cell Biol. 1988 Aug.

Abstract

Expression of mRNA for transforming growth factor alpha (TGF-alpha) and TGF-beta 1 during the fetal development of mice was evaluated by in situ hybridization. TGF-alpha mRNA was detected in 9- and 10-day fetuses but was absent in older fetuses. TGF-alpha mRNA-containing cells were found in the placenta, otic vesicle, oral cavity, pharyngeal pouch, first and second branchial arches, and developing kidneys. mRNA for TGF-beta 1 was present in hematopoietic cells of blood islands and capillaries and in the liver as it began to bud off on day 10 and function as a hematopoietic organ.

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