Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2020 Nov;130(11):2598-2606.
doi: 10.1002/lary.28523. Epub 2020 Feb 29.

The Prognostic Role of Programmed Death-Ligand 1 in Nasopharyngeal Carcinoma

Michael Wotman  1 , Saori W Herman  2 , Peter Costantino  1 , Tristan Tham  1
Affiliations
Meta-Analysis

The Prognostic Role of Programmed Death-Ligand 1 in Nasopharyngeal Carcinoma

Michael Wotman et al. Laryngoscope. 2020 Nov.

Abstract

Objectives: Programmed death-ligand 1 (PD-L1) is an immune checkpoint protein that may be a useful prognostic biomarker in nasopharyngeal cancer (NPC). The purpose of this systematic review and meta-analysis was to investigate the relationship between PD-L1 expression and survival in NPC.

Methods: PubMed, Cochrane, Embase, Scopus, and Web of Science were searched from inception to present. A predefined inclusion and exclusion criteria were used to select articles. Hazard ratios (HRs) and 95% confidence intervals (CIs) were pooled for overall survival (OS), disease-free survival (DFS), and disease metastasis-free survival (DMFS).

Results: Eleven studies published from 2014 to 2018 were included, with 1,356 total participants. PD-L1 expression was not associated with OS (HR = 1.10, 95% CI: 0.79-1.55), DFS (HR = 1.66, 95% CI: 0.68-4.03), or DMFS (HR = 1.18, 95% CI: 0.44-3.20).

Conclusions: The prognostic role of PD-L1 in NPC remains unsubstantiated. Future research is needed. Laryngoscope, 130:2598-2606, 2020.

Keywords: Head and neck neoplasms; immune checkpoint; nasopharyngeal carcinoma; prognostic biomarker; programmed death-ligand 1.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

BIBLIOGRAPHY

    1. Moore MG, ed. Quick Reference Guide to TNM Staging of Head and Neck Cancer and Neck Dissection Classification. 5th ed. Alexandria, VA: American Academy of Otolaryngology - Head and Neck Surgery Foundation/American Head and Neck Society; 2018.
    1. Hui EP, Chan AT. Epidemiology, etiology, and diagnosis of nasopharyngeal carcinoma. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. Available at: https://www.uptodate.com/contents/epidemiology-etiology-and-diagnosis-of.... Accessed May 01, 2019.
    1. Chua MLK, Wee JTS, Hui EP, Chan ATC. Nasopharyngeal carcinoma. Lancet 2016;387:1012-1024.
    1. Fang W, Zhang J, Hong S, et al. EBV-driven LMP1 and IFN-γ up-regulate PD-L1 in nasopharyngeal carcinoma: implications for oncotargeted therapy. Oncotarget 2014;5:12189-12202.
    1. Kythreotou A, Siddique A, Mauri FA, Bower M, Pinato DJ. PD-L1. J Clin Pathol 2018;71:189-194.

LinkOut - more resources