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. 2020 Aug;115(8):1580-1589.
doi: 10.1111/add.15023. Epub 2020 Mar 17.

Alcohol use disorders and the brain

Rahul Rao  1   2 , Anya Topiwala  3
Affiliations

Alcohol use disorders and the brain

Rahul Rao et al. Addiction. 2020 Aug.

Abstract

A diagnosis of alcohol use disorder is associated with a higher risk of dementia, but a dose-response relationship between alcohol intake consumption and cognitive impairment remains unclear. Alcohol is associated with a range of effects on the central nervous system at different doses and acts on a number of receptors. Acute disorders include Wernicke's encephalopathy (WE), traumatic brain injury, blackouts, seizures, stroke and hepatic encephalopathy. The most common manifestations of chronic alcohol consumption are Korsakoff's syndrome (KS) and alcohol-related dementia (ARD). There is limited evidence for benefit from memantine in the treatment of ARD, but stronger evidence for the use of high-dose parenteral thiamine in the progression of neuropsychiatric symptoms for WE. Accumulating evidence exists for pharmacological treatment in the prevention of hepatic encephalopathy. Rehabilitation of people with ARD may take several years, and requires an approach that addresses physical and psychosocial factors.

Keywords: Alcohol; Korsakoff's syndrome; Wernicke's encephalopathy; dementia: brain; hepatic encephalopathy; thiamine.

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References

    1. Office of National Statistics (ONS). Statistics on Alcohol, England. London: ONS; 2019.
    1. Grant B. F., Chou S. P., Saha T. D., Pickering R. P., Kerridge B. T., Ruan W. J. et al. Prevalence of 12-month alcohol use, high-risk drinking, and DSM-IV alcohol use disorder in the United States, 2001-2002 to 2012-2013: results from the National Epidemiologic Survey on alcohol and related conditions. JAMA Psychiatry 2017; 74: 911-923.
    1. Blazer D. G., Wu L.-T. The epidemiology of alcohol use disorders and subthreshold dependence in a middle-aged and elderly community sample. Am J Geriatr Psychiatry 2011; 19: 685-694.
    1. Plant M., Haw S. Women and alcohol: report of an expert seminar. Health Education Board for Scotland. Edinburgh: NHS Health Scotland; 2000.
    1. Langballe E. M., Ask H., Holmen J., Stordal E., Saltvedt I., Selbaek G. et al. Alcohol consumption and risk of dementia up to 27 years later in a large, population-based sample: the HUNT study, Norway. Eur J Epidemiol 2015; 30: 1049-1056.

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