Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Apr;14(1):76-77.
doi: 10.22074/ijfs.2020.5876. Epub 2020 Feb 25.

Endometriosis Classification and The Role of Tumor Necrosis Factor-Alpha Polymorphisms as A Therapeutic Target

Fabio Barra  1   2 , Lorenzo Ferro Desideri  3   2 , Umberto Leone Roberti Maggiore  3   2 , Valerio Gaetano Vellone  4 , Mattia Maramai  3   2 , Carolina Scala  3   2 , Simone Ferrero  3   2
Affiliations

Endometriosis Classification and The Role of Tumor Necrosis Factor-Alpha Polymorphisms as A Therapeutic Target

Fabio Barra et al. Int J Fertil Steril. 2020 Apr.

Abstract

In the recent original research published on International Journal of Fertility and Sterility the association between tumor necrosis factor-alpha (TNF-α) genetic polymorphisms and endometriosis in 150 Iranian patients suffered this disease. The authors notably found a lower frequency of TNF-α -863C/A allele A among the affected patients in comparison with healthy women, although this difference was not significant by adjusting multiple testing. We deem that the authors should specify, if these patients had peritoneal nodules, ovarian endometrioma/deep infiltrating endometriosis (DIE) nodules or combination of them, since it has been hypothesized that these phenotypes may represent three distinct pathogenetic entities of endometriosis.

Keywords: Endometriosis; Genetic Polymorphisms; Tumor Necrosis Factor-Alpha.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Similar articles

See all similar articles

Cited by

References

    1. Babaabasi B, Ahani A, Sadeghi F, Bashizade-Fakhar H, Khorram Khorshid HR. The association between TNF-alpha gene polymorphisms and endometriosis in an Iranian population. Int J Fertil Steril. 2019;13(1):6–11. - PMC - PubMed
    1. Varfolomeev E, Vucic D. Intracellular regulation of TNF activity in health and disease. Cytokine. 2018;101:26–32. - PubMed
    1. Wu MY, Ho HN. The role of cytokines in endometriosis. Am J Reprod Immunol. 2003;49(5):285–296. - PubMed
    1. Vercellini P, Viganò P, Somigliana E, Fedele L. Endometriosis: pathogenesis and treatment. Nat Rev Endocrinol. 2014;10(5):261–275. - PubMed
    1. Gentilini D, Vigano P, Carmignani L, Spinelli M, Busacca M, Di Blasio AM. Progesterone receptor +331G/A polymorphism in endometriosis and deep-infiltrating endometriosis. Fertil Steril. 2008;90(4):1243–1245. - PubMed

LinkOut - more resources