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. 2020 May:204:104773.
doi: 10.1016/j.bandl.2020.104773. Epub 2020 Feb 27.

Neuroanatomical correlates of phonologic errors in logopenic progressive aphasia

Diana Petroi  1 , Joseph R Duffy  2 , Andrew Borgert  3 , Edythe A Strand  2 , Mary M Machulda  4 , Matthew L Senjem  5 , Clifford R Jack Jr  6 , Keith A Josephs  2 , Jennifer L Whitwell  7
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Neuroanatomical correlates of phonologic errors in logopenic progressive aphasia

Diana Petroi et al. Brain Lang. 2020 May.

Abstract

While phonologic errors may be one of the salient features of the logopenic variant of primary progressive aphasia (lvPPA), sparse data are available on their neuroimaging correlates. The purpose of this study was to identify brain regions associated with different types of phonologic errors across several tasks for participants with lvPPA. Correlational analyses between phonologic errors across tasks most likely to elicit such errors and specific left hemisphere gray matter volume regions were conducted for 20 participants. Findings point to the inferior parietal lobe and supramarginal gyrus as being the most relevant correlates. Atrophy in these regions may increase the likelihood of making phonologic errors in lvPPA, particularly substitution error types. Our results provide support for neuroanatomical correlates of phonologic errors in the parietal region, which is consistent with previous findings of temporoparietal cortex involvement/atrophy in lvPPA.

Keywords: Logopenic progressive aphasia; Neuroanatomical correlates; Neuroimaging; Phonologic errors; Primary progressive aphasia.

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Conflict of interest statement

Declaration of Competing Interest Authors Diana Petroi, Andrew Borgert, and Edythe A. Strand do not have any disclosures. Keith A. Josephs, Jennifer L. Whitwell, Joseph R. Duffy, and Mary M. Machulda receive funding from the NIH. Matthew L. Senjem owns stocks in Align Technology, Inc., CRISPR Therapeutics, Gilead Sciences, Ionis Pharmaceuticals, Johnson & Johnson, LHC Group, Inc., Medtronic, Inc., Mesa Laboratories, Inc., Natus Medical Inc., and Varex Imaging Corporation.

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