Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2020 Apr;75(4):927-929.
doi: 10.1161/HYPERTENSIONAHA.119.14534. Epub 2020 Mar 2.

Aldosterone-Producing Adenomas: More Than Meets the Eye

Celso E Gomez-Sanchez  1   2 , Clara M Gomez-Sanchez  3 , Kenji Oki  4
Affiliations
Editorial

Aldosterone-Producing Adenomas: More Than Meets the Eye

Celso E Gomez-Sanchez et al. Hypertension. 2020 Apr.
No abstract available

PubMed Disclaimer

Figures

Figure 1;
Figure 1;
Schematic representation of an aldosterone-producing adenoma (APA) in the dominant adrenal with corresponding aldosterone levels in the contralateral adrenal. The gland bearing an APA may also have APCCs, some of which may have aldosterone-driving mutations. The contralateral adrenal may have no APCCs, APCCs without mutations and no increased aldosterone production, or APCCs with aldosterone-driving mutations leading to aldosterone concentrations in its adrenal vein several times higher than peripheral values. In the latter case, aldosterone production in the contralateral adrenal is not suppressed, however adrenal vein aldosterone levels are still much lower than from the adrenal with the APA, resulting a high lateralization index.
See this image and copyright information in PMC

Comment on

References

    1. Funder JW, Carey RM, Mantero F, Murad MH, Reincke M, Shibata H, Stowasser M, Young WF Jr., The management of primary aldosteronism: Case detection, diagnosis, and treatment: An endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2016;101:1889–1916 - PubMed
    1. Choi M, Scholl UI, Yue P, Bjorklund P, Zhao B, Nelson-Williams C, Ji W, Cho Y, Patel A, Men CJ, Lolis E, Wisgerhof MV, Geller DS, Mane S, Hellman P, Westin G, Akerstrom G, Wang W, Carling T, Lifton RP. K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension. Science. 2011;331:768–772 - PMC - PubMed
    1. Seccia TM, Caroccia B, Gomez-Sanchez EP, Gomez-Sanchez CE, Rossi GP. The biology of normal zona glomerulosa and aldosterone-producing adenoma: Pathological implications. Endocrine reviews. 2018;39:1029–1056 - PMC - PubMed
    1. De Sousa K, Boulkroun S, Baron S, Nanba K, Wack M, Rainey WE, Rocha A, Giscos-Douriez I, Meatchi T, Amar L, Travers S, Fernandes-Rosa FL, Zennaro MC. Genetic, cellular and molecular heterogeneity in adrenals with aldosterone producing adenoma. Hypertension. 2020;in press - PMC - PubMed
    1. Nanba K, Omata K, Gomez-Sanchez CE, Stratakis CA, Demidowich AP, Suzuki M, Thompson LDR, Cohen DL, Luther JM, Gellert L, Vaidya A, Barletta JA, Else T, Giordano TJ, Tomlins SA, Rainey WE. Genetic characteristics of aldosterone-producing adenomas in blacks. Hypertension. 2019;73:885–892 - PMC - PubMed