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. 2020 Aug;42(8):1994-2001.
doi: 10.1002/hed.26135. Epub 2020 Mar 1.

Positive lymph node number and extranodal extension for predicting recurrence and survival in patients with salivary gland cancer

Hojun Lee  1 , Jong-Lyel Roh  2 , Kyung-Ja Cho  3 , Seung-Ho Choi  1 , Soon Yuhl Nam  1 , Sang Yoon Kim  1
Affiliations

Positive lymph node number and extranodal extension for predicting recurrence and survival in patients with salivary gland cancer

Hojun Lee et al. Head Neck. 2020 Aug.

Abstract

Background: This study compared our proposed N classification including the addition of the number of positive lymph node (LN+) and extranodal extension (ENE) with the current and previous American Joint Committee on Cancer (AJCC) N classifications in salivary gland cancer (SGC).

Methods: This study involved 172 SGC patients who underwent surgery. Cox proportional hazard regression analyses were used to identify factors associated with overall survival (OS) and disease-free survival (DFS).

Results: In multivariate analyses, LN+ number, LN ratio, and ENE were associated with OS and DFS outcomes (all P < .05). Our new N classification proposed three categories: N0 (0 LN+), N1 (1 LN+), and N2 (≥2 LN+ or ENE). The C-index of our N classification showed improvement in OS prediction (0.768) compared with the AJCC seventh (0.743) and eighth (0.756) edition N classifications.

Conclusions: Our proposed N classification incorporating LN+ number and ENE may improve prediction of post-treatment survival and recurrence in patients with SGC.

Keywords: N classification; extranodal extension; lymph node metastasis; prognosis; salivary gland cancer.

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References

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