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Case Reports
. 2021 Dec 1;37(12):e1745-e1746.
doi: 10.1097/PEC.0000000000001952.

Antiretroviral Prophylaxis: A Digestive Complication to Know

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Case Reports

Antiretroviral Prophylaxis: A Digestive Complication to Know

Anaïs Lemoine et al. Pediatr Emerg Care. .

Abstract

An 8-year-old child experienced abdominal pain and melena due to duodenal and ileal ulcerations throughout antiretroviral prophylactic treatment after a needlestick injury. Mild to moderate adverse effects often occur with lamivudine and zidovudine, but more severe adverse effects such as intestinal ulcers resulting in melena after a prophylactic antiretroviral treatment may question the safety of the current guidelines.

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Conflict of interest statement

Disclosure: The authors declare no conflict of interest.

References

    1. Wang SA, Panlilio AL, Doi PA, et al. Experience of healthcare workers taking postexposure prophylaxis after occupational HIV exposures: findings of the HIV postexposure prophylaxis registry. Infect Control Hosp Epidemiol . 2000;21:780–785.
    1. Edwards P, Turner J, Gold J, et al. Esophageal ulceration induced by Zidovudine. Ann Intern Med . 1990;112:65–66.
    1. Desfrere L, De Oliveira I, Goffinet F, et al. Increased incidence of necrotizing enterocolitis in premature infants born to HIV-positive mothers. AIDS . 2005;19:1487–1493.
    1. Schmitz T, Weizsaecker K, Feiterna-Sperling C, et al. Exposure to HIV and antiretroviral medication as a potential cause of necrotizing enterocolitis in term neonates. AIDS . 2006;20:1082–1083.
    1. Van Der Meulen EF, Bergman KA, Kamps AWA. Necrotising enterocolitis in a term neonate with trisomy 21 exposed to maternal HIV and antiretroviral medication. Eur J Pediatr . 2009;168:113–114.

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