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Review
. 2020 Jul;47(7):654-658.
doi: 10.1111/cup.13673. Epub 2020 Mar 13.

Subacute cutaneous lupus erythematosus with positive anti-Ro antibodies following palbociclib and letrozole treatment: A case report and literature review

Eleanor Russell-Goldman  1 , Rosalynn M Nazarian  2
Affiliations
Review

Subacute cutaneous lupus erythematosus with positive anti-Ro antibodies following palbociclib and letrozole treatment: A case report and literature review

Eleanor Russell-Goldman et al. J Cutan Pathol. 2020 Jul.

Abstract

Drug-induced subacute cutaneous lupus erythematosus (DI-SCLE) is an uncommon but well-described phenomenon, most often seen in association with antihypertensives and antifungal medications. In recent years, rare reports of DI-SCLE have been described in patients being treated with targeted therapies. Herein, we describe a case of DI-SCLE in association with palbociclib and letrozole treatment for metastatic breast cancer. This report is the first known case of DI-SCLE with positive anti-Ro antibodies in this setting. We also summarize the literature describing DI-SCLE in association with targeted therapies to date and its possible association with dysregulation of the vascular endothelial growth factor pathway.

Keywords: CDK4/6 inhibitor; anti-Ro; drug-induced; palbociclib; subacute cutaneous lupus erythematosus; targeted therapy.

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