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Book

Spironolactone

Saikrishna Patibandla  1 , Joseph Heaton  2 , Htoo Kyaw  3
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Book

Spironolactone

Saikrishna Patibandla et al.
Free Books & Documents

Excerpt

Spironolactone is a medication used in the management and treatment of hypertension and heart failure with some indications aside from cardiovascular disease. It is in the mineralocorticoid receptor antagonist class of drugs. This activity reviews the indications, action, and contraindications for spironolactone as a valuable agent in the management of cardiovascular diseases and other disorders when applicable.

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Conflict of interest statement

Disclosure: Saikrishna Patibandla declares no relevant financial relationships with ineligible companies.

Disclosure: Joseph Heaton declares no relevant financial relationships with ineligible companies.

Disclosure: Htoo Kyaw declares no relevant financial relationships with ineligible companies.

References

    1. Pitt B, Zannad F, Remme WJ, Cody R, Castaigne A, Perez A, Palensky J, Wittes J. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med. 1999 Sep 02;341(10):709-17. - PubMed
    1. Yancy CW, Jessup M, Bozkurt B, Butler J, Casey DE, Colvin MM, Drazner MH, Filippatos GS, Fonarow GC, Givertz MM, Hollenberg SM, Lindenfeld J, Masoudi FA, McBride PE, Peterson PN, Stevenson LW, Westlake C. 2017 ACC/AHA/HFSA Focused Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America. J Card Fail. 2017 Aug;23(8):628-651. - PubMed
    1. McDiarmid AK, Swoboda PP, Erhayiem B, Bounford KA, Bijsterveld P, Tyndall K, Fent GJ, Garg P, Dobson LE, Musa TA, Foley JRJ, Witte KK, Kearney MT, Greenwood JP, Plein S. Myocardial Effects of Aldosterone Antagonism in Heart Failure With Preserved Ejection Fraction. J Am Heart Assoc. 2020 Jan 07;9(1):e011521. - PMC - PubMed
    1. Agrawal S, Agrawal N, Garg J, Mohandas R, Gupta T, Segal M. Heart failure and chronic kidney disease: should we use spironolactone? Am J Med Sci. 2015 Aug;350(2):147-51. - PubMed
    1. Yang CT, Kor CT, Hsieh YP. Long-Term Effects of Spironolactone on Kidney Function and Hyperkalemia-Associated Hospitalization in Patients with Chronic Kidney Disease. J Clin Med. 2018 Nov 21;7(11) - PMC - PubMed

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