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Book

Biochemistry, Ceruloplasmin

Michael J. Lopez  1 , Amor Royer  2 , Niraj J. Shah  3
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Book

Biochemistry, Ceruloplasmin

Michael J. Lopez et al.
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Excerpt

Ceruloplasmin is a serum ferroxidase responsible for 95% copper transport in the blood. It is well known for its role in the pathogenesis of Wilson disease and regulating iron metabolism. Also, ceruloplasmin is a positive acute-phase reactant, meaning its levels increase in inflammatory conditions or cell injury. Copper is a trace element that acts as a cofactor for multiple enzymes in critical cellular reactions, such as cytochromes, which participate in the electron transport chain and redox catalysis. Recent studies have shown that alterations of ceruloplasmin protein and copper homeostasis are associated with Alzheimer disease.

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Conflict of interest statement

Disclosure: Michael Lopez declares no relevant financial relationships with ineligible companies.

Disclosure: Amor Royer declares no relevant financial relationships with ineligible companies.

Disclosure: Niraj Shah declares no relevant financial relationships with ineligible companies.

References

    1. Walshe JM. Cause of death in Wilson disease. Mov Disord. 2007 Nov 15;22(15):2216-20. - PubMed
    1. Vasilyev VB. Interactions of caeruloplasmin with other proteins participating in inflammation. Biochem Soc Trans. 2010 Aug;38(4):947-51. - PubMed
    1. Twomey PJ, Viljoen A, House IM, Reynolds TM, Wierzbicki AS. Relationship between serum copper, ceruloplasmin, and non-ceruloplasmin-bound copper in routine clinical practice. Clin Chem. 2005 Aug;51(8):1558-9. - PubMed
    1. Squitti R, Quattrocchi CC, Forno GD, Antuono P, Wekstein DR, Capo CR, Salustri C, Rossini PM. Ceruloplasmin (2-D PAGE) Pattern and Copper Content in Serum and Brain of Alzheimer Disease Patients. Biomark Insights. 2007 Feb 07;1:205-13. - PMC - PubMed
    1. Squitti R, Quattrocchi CC, Salustri C, Rossini PM. Ceruloplasmin fragmentation is implicated in 'free' copper deregulation of Alzheimer's disease. Prion. 2008 Jan-Mar;2(1):23-7. - PMC - PubMed

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