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Book

Irinotecan

Gizem Reyhanoglu  1 , Travis Smith  2
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
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Affiliations
Book

Irinotecan

Gizem Reyhanoglu et al.

Excerpt

Irinotecan is a medication used to manage and treat a variety of solid tumors. It is in the DNA topoisomerase I inhibitor class of drugs. Also known as CPT-11, irinotecan is used adjunctively with other therapeutic agents against colorectal cancer as a first- or second-line treatment. This activity reviews the indications, action, and contraindications for irinotecan as a valuable agent in treating solid tumors such as colorectal, pancreatic, ovarian, and lung cancers. This activity will highlight the mechanism of action, adverse event profile, and other key factors (e.g., off-label uses, dosing, pharmacodynamics, pharmacokinetics, monitoring, relevant interactions) pertinent for healthcare team members in the care of patients who receive treatment with this medication.

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Conflict of interest statement

Disclosure: Gizem Reyhanoglu declares no relevant financial relationships with ineligible companies.

Disclosure: Travis Smith declares no relevant financial relationships with ineligible companies.

References

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    1. Emami AH, Sadighi S, Shirkoohi R, Mohagheghi MA. Prediction of Response to Irinotecan and Drug Toxicity Based on Pharmacogenomics Test: A Prospective Case Study in Advanced Colorectal Cancer. Asian Pac J Cancer Prev. 2017 Oct 26;18(10):2803-2807. - PMC - PubMed

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