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Book

Triptans

Samar Nicolas  1 , Diala Nicolas  2
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Free Books & Documents
Book

Triptans

Samar Nicolas et al.
Free Books & Documents

Excerpt

Triptans comprise a class of medications approved by the US Food and Drug Administration (FDA) as the first-line agent for treating acute migraine episodes with or without aura. In the United States, 7 triptans are available in diverse dosage formulations, including sumatriptan, naratriptan, zolmitriptan, rizatriptan, almotriptan, frovatriptan, and eletriptan. Sumatriptan, in its subcutaneous formulation, is also approved for treating cluster headaches. Almotriptan has an FDA indication for use in adolescents for treating migraines lasting at least 4 hours. The FDA has also approved zolmitriptan nasal spray for children aged 12 or older and rizatriptan for children aged 6 to 17. Frovatriptan, naratriptan, and oral zolmitriptan have off-label uses for preventing menstrual migraine.

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Conflict of interest statement

Disclosure: Samar Nicolas declares no relevant financial relationships with ineligible companies.

Disclosure: Diala Nicolas declares no relevant financial relationships with ineligible companies.

References

    1. Cady R, Schreiber C. Sumatriptan: update and review. Expert Opin Pharmacother. 2006 Aug;7(11):1503-14. - PubMed
    1. Negro A, Koverech A, Martelletti P. Serotonin receptor agonists in the acute treatment of migraine: a review on their therapeutic potential. J Pain Res. 2018;11:515-526. - PMC - PubMed
    1. Antonaci F, Ghiotto N, Wu S, Pucci E, Costa A. Recent advances in migraine therapy. Springerplus. 2016;5:637. - PMC - PubMed
    1. Eiland LS, Hunt MO. The use of triptans for pediatric migraines. Paediatr Drugs. 2010 Dec 01;12(6):379-89. - PubMed
    1. McKeage K. Zolmitriptan Nasal Spray: A Review in Acute Migraine in Pediatric Patients 12 Years of Age or Older. Paediatr Drugs. 2016 Feb;18(1):75-81. - PubMed

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