Nasopharyngeal Carcinoma
- PMID: 32119475
- Bookshelf ID: NBK554588
Nasopharyngeal Carcinoma
Excerpt
Nasopharyngeal carcinoma (NPC), previously known as lymphoepithelioma, is an undifferentiated form of squamous cell carcinoma arising from the epithelium of the nasopharynx (see Image. Nasopharyngeal Mass). It is the most common malignancy of the nasopharynx. Endemic to parts of Asia and Africa but found worldwide, the malignancy shows a variable rate of occurrence ranging from high incidence in the southern part of China (25 to 50 cases per 100,000) to a low rate in European populations (1 case per 100,000). A complex interplay of genetic susceptibility and Epstein-Barr virus (EBV) infection is responsible for these epidemiological patterns. There is a male predominance.
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Sections
- Continuing Education Activity
- Introduction
- Etiology
- Epidemiology
- Histopathology
- History and Physical
- Evaluation
- Treatment / Management
- Differential Diagnosis
- Staging
- Prognosis
- Complications
- Consultations
- Deterrence and Patient Education
- Pearls and Other Issues
- Enhancing Healthcare Team Outcomes
- Review Questions
- References
References
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- Chang ET, Adami HO. The enigmatic epidemiology of nasopharyngeal carcinoma. Cancer Epidemiol Biomarkers Prev. 2006 Oct;15(10):1765-77. - PubMed
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- Sun L, Wang Y, Shi J, Zhu W, Wang X. Association of Plasma Epstein-Barr Virus LMP1 and EBER1 with Circulating Tumor Cells and the Metastasis of Nasopharyngeal Carcinoma. Pathol Oncol Res. 2020 Jul;26(3):1893-1901. - PubMed
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