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Young's Rule is an equation used to calculate pediatric medication dosage based on patient age and the known recommended adult dose. The definition of Young's Rule is the age of the patient divided by the age added to twelve, all multiplied by the recommended adult dose. This formula appears below:
Mahmood I. A comparison of different methods for the first-in-pediatric dose selection. J Clin Transl Res. 2022 Oct 31;8(5):369-381.
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Delgado BJ, Safadi AO, Bajaj T. StatPearls [Internet] StatPearls Publishing; Treasure Island (FL): 2023. Jul 30, Clark's Rule.
Ogden CL, Carroll MD, Lawman HG, Fryar CD, Kruszon-Moran D, Kit BK, Flegal KM. Trends in Obesity Prevalence Among Children and Adolescents in the United States, 1988-1994 Through 2013-2014. JAMA. 2016 Jun 07;315(21):2292-9.
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Kendrick JG, Carr RR, Ensom MH. Pharmacokinetics and drug dosing in obese children. J Pediatr Pharmacol Ther. 2010 Apr;15(2):94-109.
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Wang K, Jiang K, Wei X, Li Y, Wang T, Song Y. Physiologically Based Pharmacokinetic Models Are Effective Support for Pediatric Drug Development. AAPS PharmSciTech. 2021 Jul 26;22(6):208.
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