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Review
. 2020 Jun 15:170:108022.
doi: 10.1016/j.neuropharm.2020.108022. Epub 2020 Feb 29.

Genetic causes of PD: A pathway to disease modification

M Toffoli  1 , S R L Vieira  1 , A H V Schapira  2
Affiliations
Review

Genetic causes of PD: A pathway to disease modification

M Toffoli et al. Neuropharmacology. .

Abstract

The underline neuropathology of Parkinson disease is pleiomorphic and its genetic background diverse. Possibly because of this heterogeneity, no effective disease modifying therapy is available. In this paper we give an overview of the genetics of Parkinson disease and explain how this is relevant for the development of new therapies. This article is part of the special issue entitled 'The Quest for Disease-Modifying Therapies for Neurodegenerative Disorders'.

Keywords: Disease modifying; GBA1; Genetics; LRRK2; Parkinson disease; SNCA; Therapy.

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