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Review
. 2020 Feb 28;21(5):1645.
doi: 10.3390/ijms21051645.

Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases

Madhulika Tripathi  1 , Paul Michael Yen  1 , Brijesh Kumar Singh  1
Affiliations
Review

Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases

Madhulika Tripathi et al. Int J Mol Sci. .

Abstract

The estrogen-related receptor alpha (ESRRA) is an orphan nuclear receptor (NR) that significantly influences cellular metabolism. ESRRA is predominantly expressed in metabolically-active tissues and regulates the transcription of metabolic genes, including those involved in mitochondrial turnover and autophagy. Although ESRRA activity is well-characterized in several types of cancer, recent reports suggest that it also has an important role in metabolic diseases. This minireview focuses on the regulation of cellular metabolism and function by ESRRA and its potential as a target for the treatment of metabolic disorders.

Keywords: Estrogen-related receptor alpha; adaptive thermogenesis; adipogenesis; metabolic diseases; mitochondrial turnover; mitophagy; non-alcoholic fatty liver disease (NAFLD).

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Conflict of interest statement

The authors declare no conflicts of interest.

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