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Editorial
. 2020 Mar 3;9(5):e015726.
doi: 10.1161/JAHA.120.015726. Epub 2020 Mar 3.

Long-Term Ticagrelor Versus Prasugrel Pharmacodynamics in Patients With ST-Segment-Elevation Myocardial Infarction

Affiliations
Editorial

Long-Term Ticagrelor Versus Prasugrel Pharmacodynamics in Patients With ST-Segment-Elevation Myocardial Infarction

Salvatore Cassese et al. J Am Heart Assoc. .
No abstract available

Keywords: Editorials; P2Y12 receptor; endothelial function; percutaneous transluminal coronary angioplasty; platelet aggregation.

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Figures

Figure 1
Figure 1
Endothelial function with ticagrelor vs prasugrel maintenance dose. The weighted mean difference, with 95% CIs, was used as summary statistic to compare the endothelial function in patients receiving either ticagrelor or prasugrel. The risk estimates were pooled using the inverse variance method for the random‐effect model, and P<0.05 was considered statistically significant. The I2 statistic tested heterogeneity across the trials, and the chi‐square test examined whether the treatment effect was dependent on the methods quantifying the endothelial function. For the studies of Schnorbus et al7 and Xanthopoulou et al,14 means and standard deviations (SD) were derived from median and interquartile ranges, according to Hozo et al.16

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References

    1. Ibanez B, James S, Agewall S, Antunes MJ, Bucciarelli‐Ducci C, Bueno H, Caforio ALP, Crea F, Goudevenos JA, Halvorsen S, Hindricks G, Kastrati A, Lenzen MJ, Prescott E, Roffi M, Valgimigli M, Varenhorst C, Vranckx P, Widimsky P; ESC Scientific Document Group . 2017 ESC guidelines for the management of acute myocardial infarction in patients presenting with ST‐segment elevation: the Task Force for the management of acute myocardial infarction in patients presenting with ST‐segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2018;39:119–177. - PubMed
    1. Steg PG, James S, Harrington RA, Ardissino D, Becker RC, Cannon CP, Emanuelsson H, Finkelstein A, Husted S, Katus H, Kilhamn J, Olofsson S, Storey RF, Weaver WD, Wallentin L; PLATO Study Group . Ticagrelor versus clopidogrel in patients with ST‐elevation acute coronary syndromes intended for reperfusion with primary percutaneous coronary intervention: a Platelet Inhibition and Patient Outcomes (PLATO) trial subgroup analysis. Circulation. 2010;122:2131–2141. - PubMed
    1. Montalescot G, Wiviott SD, Braunwald E, Murphy SA, Gibson CM, McCabe CH, Antman EM; TRITON‐TIMI 38 Investigators . Prasugrel compared with clopidogrel in patients undergoing percutaneous coronary intervention for ST‐elevation myocardial infarction (TRITON‐TIMI 38): double‐blind, randomised controlled trial. Lancet. 2009;373:723–731. - PubMed
    1. Moulias A, Xanthopoulou I, Alexopoulos D. Does ticagrelor improve endothelial function? J Cardiovasc Pharmacol Ther. 2019;24:11–17. - PubMed
    1. Franchi F, Rollini F, Angiolillo DJ. Antithrombotic therapy for patients with STEMI undergoing primary PCI. Nat Rev Cardiol. 2017;14:361–379. - PubMed

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