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Review
. 2020 May;130(1):1-6.
doi: 10.1016/j.ymgme.2020.02.007. Epub 2020 Feb 21.

Clinical and biochemical footprints of inherited metabolic diseases. III. Psychiatric presentations

Gabriella A Horvath  1 , Robert M Stowe  2 , Carlos R Ferreira  3 , Nenad Blau  4
Affiliations
Review

Clinical and biochemical footprints of inherited metabolic diseases. III. Psychiatric presentations

Gabriella A Horvath et al. Mol Genet Metab. 2020 May.

Abstract

Psychiatric symptoms are common manifestations in many inborn errors of metabolism (IEMs), ranging from attention deficit, anxiety and mood and behavioral disorders to psychosis. Furthermore, IEMs represent a significant percentage of all autism cases. We reviewed and updated the list of metabolic disorders known to be associated with various psychiatric manifestations and found more than 100 relevant IEMs. This represents the third of a series of articles attempting to create and maintain a comprehensive list of clinical and metabolic differential diagnoses according to organ system involvement.

Keywords: Aggressive behavior; Anxiety; Autism spectrum disorder; Behavioral disorder; Depression; Hyperactivity; Inborn errors of metabolism; Obsessive compulsive disorder; Psychiatric disorders; Psychosis.

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Conflict of interest statement

Declaration of Competing Interest None.

Figures

Figure 1.
Figure 1.
Occurrence (%) of symptoms associated with psychiatric disorders in Top-15 groups of 64 IEMs. The percentages of particular psychiatric syndromes occurring in each psychiatric disorder were calculated using the total number of IEMs in each category presenting with any psychiatric disorder as the denominator. Heat scale ranges from red (0%) for diseases with no particular symptoms reported to violet (100%) for diseases with particular symptoms being highly characteristic.
See this image and copyright information in PMC

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