Infectious mononucleosis, immune genotypes, and non-Hodgkin lymphoma (NHL): an InterLymph Consortium study

Niquelle Brown Wadé^{1

2}, Cindy M Chang³, David Conti^{1

4}, Joshua Millstein^{1

4}, Christine Skibola⁵, Alexandra Nieters⁶, Sophia S Wang⁷, Silvia De Sanjose^{8

9}, Eleanor Kane¹⁰, John J Spinelli^{11

12}, Paige Bracci¹³, Yawei Zhang¹⁴, Susan Slager¹⁵, Jun Wang^{1

4}, Henrik Hjalgrim^{16

17}, Karin Ekstrom Smedby¹⁸, Elizabeth E Brown¹⁹, Ruth F Jarrett²⁰, Wendy Cozen^{21

22

23}; InterLymph Consortium Immunology and Infection Working Group

Affiliations

¹ Department of Preventive Medicine, Center for Genetic Epidemiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
² Cigna Health and Life Insurance Company (Cigna), Bloomfield, CT, USA.
³ Division of Population Health Sciences, Center for Tobacco Products, Food and Drug Administration, Bethesda, MD, USA.
⁴ USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
⁵ Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA.
⁶ Center for Chronic Immunodeficiency (CCI), University Medical Center Freiburg, University of Freiburg, Freiburg, Germany.
⁷ Department of Computational and Quantitative Medicine, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.
⁸ Sexual and Reproductive Health, PATH, Seattle, WA, USA.
⁹ Centro de Investigación Biomédica en Red: Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
¹⁰ Department of Health Sciences, University of York, York, YO10 5DD, UK.
¹¹ Population Oncology, BC Cancer Agency, Vancouver, Canada.
¹² School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada.
¹³ Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA, USA.
¹⁴ Department of Surgery, Yale School of Medicine and Yale School of Public Health, New Haven, CT, USA.
¹⁵ Department of Epidemiology, Mayo Clinic, Rochester, MN, USA.
¹⁶ Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
¹⁷ Department of Haematology, Rigshospitalet, Copenhagen, Denmark.
¹⁸ Karolinska Institutet, Sweden University Hospital, Karolinska University, Stockholm, Sweden.
¹⁹ Department of Pathology, O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, USA.
²⁰ MRC-University of Glasgow Centre for Virus Research, Glasgow, Scotland.
²¹ Department of Preventive Medicine, Center for Genetic Epidemiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. wcozen@med.usc.edu.
²² USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. wcozen@med.usc.edu.
²³ Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA. wcozen@med.usc.edu.

PMID: 32124188
PMCID: PMC7534692
DOI: 10.1007/s10552-020-01266-4

Infectious mononucleosis, immune genotypes, and non-Hodgkin lymphoma (NHL): an InterLymph Consortium study

Niquelle Brown Wadé et al. Cancer Causes Control. 2020 May.

. 2020 May;31(5):451-462.

doi: 10.1007/s10552-020-01266-4. Epub 2020 Mar 2.

Authors

Affiliations

¹ Department of Preventive Medicine, Center for Genetic Epidemiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
² Cigna Health and Life Insurance Company (Cigna), Bloomfield, CT, USA.
³ Division of Population Health Sciences, Center for Tobacco Products, Food and Drug Administration, Bethesda, MD, USA.
⁴ USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
⁵ Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA.
⁶ Center for Chronic Immunodeficiency (CCI), University Medical Center Freiburg, University of Freiburg, Freiburg, Germany.
⁷ Department of Computational and Quantitative Medicine, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.
⁸ Sexual and Reproductive Health, PATH, Seattle, WA, USA.
⁹ Centro de Investigación Biomédica en Red: Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
¹⁰ Department of Health Sciences, University of York, York, YO10 5DD, UK.
¹¹ Population Oncology, BC Cancer Agency, Vancouver, Canada.
¹² School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada.
¹³ Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA, USA.
¹⁴ Department of Surgery, Yale School of Medicine and Yale School of Public Health, New Haven, CT, USA.
¹⁵ Department of Epidemiology, Mayo Clinic, Rochester, MN, USA.
¹⁶ Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
¹⁷ Department of Haematology, Rigshospitalet, Copenhagen, Denmark.
¹⁸ Karolinska Institutet, Sweden University Hospital, Karolinska University, Stockholm, Sweden.
¹⁹ Department of Pathology, O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, USA.
²⁰ MRC-University of Glasgow Centre for Virus Research, Glasgow, Scotland.
²¹ Department of Preventive Medicine, Center for Genetic Epidemiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. wcozen@med.usc.edu.
²² USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. wcozen@med.usc.edu.
²³ Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA. wcozen@med.usc.edu.

PMID: 32124188
PMCID: PMC7534692
DOI: 10.1007/s10552-020-01266-4

Erratum in

Correction to: Infectious mononucleosis, immune genotypes, and non-Hodgkin lymphoma (NHL): an InterLymph Consortium study.
Wadé NB, Chang CM, Conti D, Millstein J, Skibola C, Nieters A, Wang SS, De Sanjose S, Kane E, Spinelli JJ, Bracci P, Zhang Y, Slager S, Wang J, Hjalgrim H, Smedby KE, Brown EE, Jarrett RF, Cozen W; InterLymph Consortium Immunology and Infection Working Group. Wadé NB, et al. Cancer Causes Control. 2020 Jun;31(6):607. doi: 10.1007/s10552-020-01297-x. Cancer Causes Control. 2020. PMID: 32227299

Abstract

Purpose: We explored the interaction between non-Hodgkin lymphoma (NHL), infectious mononucleosis (IM) history, and immune-related genotypes in a pooled case-control analysis.

Methods: A total of 7,926 NHL patients and 10,018 controls from 12 case-control studies were included. Studies were conducted during various time periods between 1988 and 2008, and participants were 17-96 years of age at the time of ascertainment/recruitment. Self-reported IM history and immune response genotypes were provided by the InterLymph Data Coordinating Center at Mayo Clinic. Odds ratios (OR) were estimated using multivariate logistic regression, and interactions were estimated using the empirical Bayes method. P_ACT was used to account for multiple comparisons.

Results: There was evidence of an interaction effect between IM history and two variants on T-cell lymphoma (TCL) risk: rs1143627 in interleukin-1B (IL1B) (p_interaction = 0.04, OR_interaction = 0.09, 95% confidence interval [CI] 0.01, 0.87) and rs1800797 in interleukin-6 (IL6) (p_interaction = 0.03, OR_interaction = 0.08, 95% CI 0.01, 0.80). Neither interaction effect withstood adjustment for multiple comparisons. There were no statistically significant interactions between immune response genotypes and IM on other NHL subtypes.

Conclusions: Genetic risk variants in IL1B and IL6 may affect the association between IM and TCL, possibly by influencing T-cell activation, growth, and differentiation in the presence of IM, thereby decreasing risk of immune cell proliferation.

Keywords: Gene–environment interaction; Infectious mononucleosis; Interleukin-1beta (IL1B); Interleukin-6 (IL6); Non-Hodgkin lymphoma; T-cell lymphoma.

PubMed Disclaimer

References

1. Morton LM, Sampson JN, Cerhan JR, Turner JJ, Vajdic CM, Wang SS, Smedby KE, De Sanjosé S, Monnereau A, Benavente Y, Bracci PM, Chiu BCH, Skibola CF, Zhang Y, Mbulaiteye SM, Spriggs M, Robinson D, Norman AD, Kane EV, Spinelli JJ, Kelly JL, La Vecchia C, Maso LD, Maynadié M, Kadin ME, Cocco P, Costantini AS, Clarke CA, Roman E, Miligi L, Colt JS, Berndt SI, Mannetje A, de Roos AJ, Kricker A, Nieters A, Franceschi S, Melbye M, Boffetta P, Clavel J, Linet MS, Weisenburger DD, Slager SL (2014) Rationale and design of the international lymphoma epidemiology consortium (interlymph) non-Hodgkin lymphoma subtypes project. J Natl Cancer Inst Monogr 2014:1–14. 10.1093/jncimonographs/lgu005 - DOI - PMC - PubMed
1. Grulich AE, Vajdic CM, Cozen W (2007) Altered immunity as a risk factor for non-Hodgkin lymphoma. Cancer Epidemiol Biomarkers Prev 16:405–409 - PubMed
1. Morton LM, Wang SS, Cozen W, Linet MS, Chatterjee N, Davis S, Severson RK, Colt JS, Vasef MA, Rothman N, Blair A, Bernstein L, Cross AJ, De Roos AJ, Engels E a., Hein DW, Hill D a., Kelemen LE, Lim U, Lynch CF, Schenk M, Wacholder S, Ward MH, Zahm SH, Chanock SJ, Cerhan JR, Hartge P (2008) Etiologic heterogeneity among non-Hodgkin lymphoma subtypes. Blood 112:5150–5160. 10.1182/blood-2008-01-133587 - DOI - PMC - PubMed
1. Smedby KE, Vajdic CM, Falster M, Engels EA, Martinez-Maza O, Turner J, Hjalgrim H, Vineis P, Costantini AS, Bracci PM, Holly EA, Willett E, Spinelli JJ, La VC, Zheng T, Becker N, De Sanjosé S, Chiu BCH, Maso LD, Cocco P, Maynadie M, Foretova L, Staines A, Brennan P, Davis S, Severson R, Cerhan JR, Breen EC, Birmann B, Grulich AE, Cozen W (2008) Autoimmune disorders and risk of non-Hodgkin lymphoma subtypes: a pooled analysis within the InterLymph Consortium. Blood 111:4029–4038. 10.1182/blood-2007-10-119974 - DOI - PMC - PubMed
1. Cozen W, Cerhan JR, Martinez-Maza O, Ward MH, Linet M, Colt JS, Davis S, Severson RK, Hartge P, Bernstein L (2007) The effect of atopy, childhood crowding, and other immune-related factors on non-Hodgkin lymphoma risk. Cancer Causes Control 18:821–831. 10.1007/s10552-007-9025-5 - DOI - PubMed

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Grants and funding

LinkOut - more resources

Full Text Sources
Medical
- MedlinePlus Health Information
Miscellaneous
- NCI CPTAC Assay Portal

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Infectious mononucleosis, immune genotypes, and non-Hodgkin lymphoma (NHL): an InterLymph Consortium study

Affiliations

Infectious mononucleosis, immune genotypes, and non-Hodgkin lymphoma (NHL): an InterLymph Consortium study

Authors

Affiliations

Erratum in

Abstract

References

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical

Miscellaneous