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. 2020 Jan 13:20:257-260.
doi: 10.1016/j.jor.2020.01.013. eCollection 2020 Jul-Aug.

Association of catechol-O-methyltranferase 472G>A (Val158Met) polymorphism with susceptibility to fibromyalgia syndrome

Maryam Hatami  1 , Mohammad Reza Sobhan  2 , Seyed Alireza Dastgheib  3 , Mohammad Hossein Jarahzadeh  1 , Mohammadali Jafari  4 , Amirhossein Yadegari  5 , Jalal Sadeghizadeh-Yazdi  6 , Hossein Neamatzadeh  7   8
Affiliations

Association of catechol-O-methyltranferase 472G>A (Val158Met) polymorphism with susceptibility to fibromyalgia syndrome

Maryam Hatami et al. J Orthop. .

Erratum in

Abstract

Background: Several lines of research have suggested that the 472G > A (Val158Met) polymorphism at Catechol-O-methyltranferase (COMT) gene is implicated in the pathophysiology of FMS. Here, we have evaluated the association of COMT 472G > A polymorphism with risk of FMS.

Methods: In this study 250 patients with FMS and 250 healthy controls were evaluated for COMT 472G > A polymorphism by RFLP-PCR assay.

Results: There were no significant differences in the allele and genotype frequencies of COMT 472G > A polymorphism between FMS cases and healthy controls.

Conclusions: Our results suggested that the COMT 472G > A polymorphism may not be risk factor for development of FMS.

Keywords: Catechol-O-Methyltransferase; Fibromyalgia; Pain; Polymorphism.

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References

    1. Lee Y.H., Choi S.J., Ji J.D., Song G.G. Candidate gene studies of fibromyalgia: a systematic review and meta-analysis. Rheumatol Int. 2012;32(2):417–426. - PubMed
    1. Tander B., Gunes S., Boke O. Polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase genes: a study on fibromyalgia susceptibility. Rheumatol Int. 2008;28(7):685–691. - PubMed
    1. Prevalence - National Fibromyalgia Association (NFA) National Fibromyalgia Association (NFA) http://www.fmaware.org/about-fibromyalgia/prevalence/
    1. Marques A.P., de S do E Santo A., Berssaneti A.A., Matsutani L.A., Yuan S.L.K. Prevalence of fibromyalgia: literature review update. Rev Bras Reumatol. 2017;57(4):356–363. - PubMed
    1. Inanir A., Karakus N., Ates O. Clinical symptoms in fibromyalgia are associated to catechol -O- methyltransferase (COMT) gene Val158Met polymorphism. Xenobiotica. 2014;44(10):952–956. - PubMed

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