Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Dec;19(4):3217-3224.
doi: 10.4314/ahs.v19i4.45.

C - reactive protein and urinary tract infection due to Gram-negative bacteria in a pediatric population at a tertiary hospital, Mwanza, Tanzania

Martha F Mushi  1 , Vaileth G Alex  1 , Mwanaisha Seugendo  2 , Vitus Silago  1 , Stephen E Mshana  1
Affiliations

C - reactive protein and urinary tract infection due to Gram-negative bacteria in a pediatric population at a tertiary hospital, Mwanza, Tanzania

Martha F Mushi et al. Afr Health Sci. 2019 Dec.

Abstract

Introduction: Gram-negative bacteria are the major cause of urinary tract infections (UTI) in children. There is limited data on UTI systemic response as measured using C-reactive protein (CRP). Here, we report the association of CRP and UTI among children attending the Bugando Medical Centre, Mwanza, Tanzania.

Methods: A cross-sectional study was conducted between May and July 2017. Urine and blood were collected and processed within an hour of collection. Data were analyzed using STATA version 13.

Results: Of 250 enrolled children, 76(30.4%) had significant bacteriuria with 56(22.4%, 95%CI; 11.5-33.3) having gram-negative bacteria infection. There was dual growth of gram-negative bacteria in 3 patients. Escherichia coli (32.2%, 19/59) was the most frequently pathogen detected. A total of 88/250(35.2%) children had positive CRP on qualitative assay. By multinomial logistic regression, positive CRP (RRR=4.02, 95%CI: 2.1-7.7, P<0.001) and age ≤ 2years (RRR=2.4, 95%CI: 1.23-4.73, P<0.01) significantly predicted the presence of significant bacteriuria due to gram-negative enteric bacteria.

Conclusion: C-reactive protein was significantly positive among children with UTI due to gram-negative bacteria and those with fever. In children with age ≤ 2 years, positive CRP indicates UTI due to gram-negative enteric bacteria.

Keywords: C - reactive protein; Gram-negative bacteria; Mwanza; Tanzania; urinary tract infection.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Antibiotic resistant patterns of gram negative bacteria isolates causing UTI among children at BMC.
See this image and copyright information in PMC

References

    1. Ahmed M, Moremi N, Mirambo MM, Hokororo A, Mushi MF, Seni J, Kamugisha E, Mshana SE. Multi-resistant gram negative enteric bacteria causing urinary tract infection among malnourished underfives admitted at a tertiary hospital, northwestern, Tanzania. Italian Journal of Ppediatrics. 2015;41(1):44. - PMC - PubMed
    1. Msaki BP, Mshana SE, Hokororo A, Mazigo HD, Morona D. Prevalence and predictors of urinary tract infection and severe malaria among febrile children attending Makongoro health centre in Mwanza city, North-Western Tanzania. Archives of Public Health. 2012;70(1):4. - PMC - PubMed
    1. Festo E, Kidenya BR, Hokororo A, Mshana SE. Predictors of urinary tract infection among febrile children attending at Bugando Medical Centre Northwestern, Tanzania. Archives of Clinical Microbiology. 2011
    1. Weinstein RA, Gaynes R, Edwards JR. Overview of nosocomial infections caused by gram-negative bacilli. Clinical Infectious Diseases. 2005;41(6):848–854. - PubMed
    1. Christopher A, Mshana SE, Kidenya BR, Hokororo A, Morona D. Bacteremia and resistant gram-negative pathogens among under-fives in Tanzania. Italian Journal of Pediatrics. 2013;39(1):27. - PMC - PubMed

MeSH terms