Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Nov 14;7(22):3887-3890.
doi: 10.3889/oamjms.2019.526. eCollection 2019 Nov 30.

Atherosclerosis Prediction with High Sensitivity C-Reactive Protein (hs-CRP) and Related Risk Factor in Patient with Dyslipidemia

Dewa Ayu Swastini  1 , Ida Ayu Dewi Wiryanthini  2 , Ni Luh Putu Ariastuti  2 , Agus Muliantara  3
Affiliations

Atherosclerosis Prediction with High Sensitivity C-Reactive Protein (hs-CRP) and Related Risk Factor in Patient with Dyslipidemia

Dewa Ayu Swastini et al. Open Access Maced J Med Sci. .

Abstract

Background: Inflammation plays a major role in the initiation, destabilization and the progression of atherosclerosis. High Sensitivity C-Reactive Protein (hs-CRP) reflects active systemic inflammation and have shown to be a strong predictor of future cardiovascular events.

Aim: The purpose of this study was to determine the role of High Sensitivity C-Reactive Protein (hs-CRP) independent for atherosclerosis severity prediction and to find out which factors largely is affecting hs-CRP level in dyslipidemia patient.

Methods: A total of 388 patients (267 dyslipidemia, 121 controls) were enrolled in this study. We investigated whether plasma hs-CRP is associated with atherosclerosis severity that was quantified by ankle-brachial index (ABI) and Doppler ultrasound. Related risk factor that influence hs-CRP levels in patients with dyslipidemia included determination of age, gender, diabetes, smoking, hypertension, total cholesterol, TG, LDL, HDL, and fasting glucose.

Results: Data showed a significant association between hs-CRP concentration level and the severity of atherosclerosis (p < 0.01). Univariate analysis showed that fasting plasma glucose, triglyceride, and BMI were significantly positively correlated with hs-CRP levels. Whereas, HDL cholesterol was negatively correlated with hs-CRP levels. Multivariate regression analysis using model 1 and 2, showed that in determining hs-CRP levels, triglyceride and BMI were taking a big role.

Conclusion: Hs-CRP correlates with extent of atherosclerosis, and high triglyceride and BMI is closely associated with high hs-CRP levels in patients with dyslipidemia.

Keywords: Atherosclerosis; Dyslipidemia; Hs-CRP.

PubMed Disclaimer

References

    1. Hajilooi M. Ghanbili. Other Systemic Responses to Inflammation. The New J. Evaluation of C-Reactive Protein, a Sensitive Marker. England Journal of Medicine. 1999;340(6):448–454. https://doi.org/10.1056/NEJM199902113400607 PMid:9971870. - PubMed
    1. Lind L. Circulating markers of inflammation and atherosclerosis. Atherosclerosis. 2003;169(2):203–14. https://doi.org/10.1016/S0021-9150(03)00012-1. - PubMed
    1. Zwaka TP, Hombach V, Torzewski J. C-reactive protein-mediated low density lipoprotein uptake by macrophages:implications for atherosclerosis. Circulation. 2001;103(9):1194–7. https://doi.org/10.1161/01.CIR.103.9.1194 PMid:11238260. - PubMed
    1. Emerging Risk Factors Collaboration. C-reactive protein, fibrinogen, and cardiovascular disease prediction. NEnglJMed. 2012;367(14):1310–20. https://doi.org/10.1056/NEJMoa1107477 PMid:23034020 PMCid:PMC3714101. - PMC - PubMed
    1. Fonseca FA, Izar MC. High-sensitivity C-reactive protein and cardiovascular disease across countries and ethnicities. Clinics. 2016;71(4):235–42. https://doi.org/10.6061/clinics/2016(04)11. - PMC - PubMed

LinkOut - more resources